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Low-complexity domain of U1-70K modulates phase separation and aggregation through distinctive basic-acidic motifs
Liquid-liquid phase separation (LLPS) facilitates the formation of functional membraneless organelles and recent reports have linked this phenomenon to protein aggregation in neurodegenerative diseases. Understanding the mechanism of LLPS and its regulation thus promises to shed light on the pathoge...
Autores principales: | Xue, Song, Gong, Rui, He, Fanqi, Li, Yanqin, Wang, Yunjia, Tan, Tianwei, Luo, Shi-Zhong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834393/ https://www.ncbi.nlm.nih.gov/pubmed/31723601 http://dx.doi.org/10.1126/sciadv.aax5349 |
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