Cargando…
Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway
Adipose tissue-derived adipokines mediate various kind of crosstalk between adipose tissue and other organs and thus regulate metabolism balance, inflammation state as well as disease progression. In particular, omentin-1, a newly found adipokine, has been reported to exhibit anti-calcification effe...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834406/ https://www.ncbi.nlm.nih.gov/pubmed/31659144 http://dx.doi.org/10.18632/aging.102251 |
_version_ | 1783466481681432576 |
---|---|
author | Xu, Feng Li, Fu-Xing-Zi Lin, Xiao Zhong, Jia-Yu Wu, Feng Shan, Su-Kang Tan, Chang-Ming Yuan, Ling-Qing Liao, Xiao-Bo |
author_facet | Xu, Feng Li, Fu-Xing-Zi Lin, Xiao Zhong, Jia-Yu Wu, Feng Shan, Su-Kang Tan, Chang-Ming Yuan, Ling-Qing Liao, Xiao-Bo |
author_sort | Xu, Feng |
collection | PubMed |
description | Adipose tissue-derived adipokines mediate various kind of crosstalk between adipose tissue and other organs and thus regulate metabolism balance, inflammation state as well as disease progression. In particular, omentin-1, a newly found adipokine, has been reported to exhibit anti-calcification effects in vitro and in vivo. However, little is known about the function of endogenous adipose tissue-derived omentin-1 in arterial calcification and the detailed mechanism involved. Here, we demonstrated that global omentin-1 knockout (omentin-1(-/-)) resulted in more obvious arterial calcification in 5/6-nephrectomy plus high phosphate diet treated (5/6 NTP) mice while overexpression of omentin-1 attenuated attenuates osteoblastic differentiation and mineralisation of VSMCs in vitro and 5/6 NTP-induced mice arterial calcification in vivo. Moreover, we found that omentin-1 induced AMPK and Akt activation while inhibition of AMP-activated protein kinase (AMPK) and Akt signaling reversed the anti-calcification effect induced by omentin-1 both in vitro and in vivo. Our results suggest that adipose tissue-derived omentin-1 serves as a potential therapeutic target for arterial calcification and cardiovascular disease. |
format | Online Article Text |
id | pubmed-6834406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-68344062019-11-13 Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway Xu, Feng Li, Fu-Xing-Zi Lin, Xiao Zhong, Jia-Yu Wu, Feng Shan, Su-Kang Tan, Chang-Ming Yuan, Ling-Qing Liao, Xiao-Bo Aging (Albany NY) Research Paper Adipose tissue-derived adipokines mediate various kind of crosstalk between adipose tissue and other organs and thus regulate metabolism balance, inflammation state as well as disease progression. In particular, omentin-1, a newly found adipokine, has been reported to exhibit anti-calcification effects in vitro and in vivo. However, little is known about the function of endogenous adipose tissue-derived omentin-1 in arterial calcification and the detailed mechanism involved. Here, we demonstrated that global omentin-1 knockout (omentin-1(-/-)) resulted in more obvious arterial calcification in 5/6-nephrectomy plus high phosphate diet treated (5/6 NTP) mice while overexpression of omentin-1 attenuated attenuates osteoblastic differentiation and mineralisation of VSMCs in vitro and 5/6 NTP-induced mice arterial calcification in vivo. Moreover, we found that omentin-1 induced AMPK and Akt activation while inhibition of AMP-activated protein kinase (AMPK) and Akt signaling reversed the anti-calcification effect induced by omentin-1 both in vitro and in vivo. Our results suggest that adipose tissue-derived omentin-1 serves as a potential therapeutic target for arterial calcification and cardiovascular disease. Impact Journals 2019-10-25 /pmc/articles/PMC6834406/ /pubmed/31659144 http://dx.doi.org/10.18632/aging.102251 Text en Copyright © 2019 Xu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Xu, Feng Li, Fu-Xing-Zi Lin, Xiao Zhong, Jia-Yu Wu, Feng Shan, Su-Kang Tan, Chang-Ming Yuan, Ling-Qing Liao, Xiao-Bo Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway |
title | Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway |
title_full | Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway |
title_fullStr | Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway |
title_full_unstemmed | Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway |
title_short | Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway |
title_sort | adipose tissue-derived omentin-1 attenuates arterial calcification via ampk/akt signaling pathway |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834406/ https://www.ncbi.nlm.nih.gov/pubmed/31659144 http://dx.doi.org/10.18632/aging.102251 |
work_keys_str_mv | AT xufeng adiposetissuederivedomentin1attenuatesarterialcalcificationviaampkaktsignalingpathway AT lifuxingzi adiposetissuederivedomentin1attenuatesarterialcalcificationviaampkaktsignalingpathway AT linxiao adiposetissuederivedomentin1attenuatesarterialcalcificationviaampkaktsignalingpathway AT zhongjiayu adiposetissuederivedomentin1attenuatesarterialcalcificationviaampkaktsignalingpathway AT wufeng adiposetissuederivedomentin1attenuatesarterialcalcificationviaampkaktsignalingpathway AT shansukang adiposetissuederivedomentin1attenuatesarterialcalcificationviaampkaktsignalingpathway AT tanchangming adiposetissuederivedomentin1attenuatesarterialcalcificationviaampkaktsignalingpathway AT yuanlingqing adiposetissuederivedomentin1attenuatesarterialcalcificationviaampkaktsignalingpathway AT liaoxiaobo adiposetissuederivedomentin1attenuatesarterialcalcificationviaampkaktsignalingpathway |