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CD8+CXCR5+T cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis

CD8+ T cells are thought to be the primary cytotoxic lymphocytes exerting antitumor effects. However, few studies have focused on the antitumor effects of CD8+ T cell-mediated humoral immunity or on interactions between CD8+ T cells and B cells in hepatocellular carcinoma (HCC). We found that the fr...

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Autores principales: Ye, Linsen, Li, Yang, Tang, Hui, Liu, Wei, Chen, Yunhao, Dai, Tianxing, Liang, Rongpu, Shi, Mengchen, Yi, Shuhong, Chen, Guihua, Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834425/
https://www.ncbi.nlm.nih.gov/pubmed/31663864
http://dx.doi.org/10.18632/aging.102308
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author Ye, Linsen
Li, Yang
Tang, Hui
Liu, Wei
Chen, Yunhao
Dai, Tianxing
Liang, Rongpu
Shi, Mengchen
Yi, Shuhong
Chen, Guihua
Yang, Yang
author_facet Ye, Linsen
Li, Yang
Tang, Hui
Liu, Wei
Chen, Yunhao
Dai, Tianxing
Liang, Rongpu
Shi, Mengchen
Yi, Shuhong
Chen, Guihua
Yang, Yang
author_sort Ye, Linsen
collection PubMed
description CD8+ T cells are thought to be the primary cytotoxic lymphocytes exerting antitumor effects. However, few studies have focused on the antitumor effects of CD8+ T cell-mediated humoral immunity or on interactions between CD8+ T cells and B cells in hepatocellular carcinoma (HCC). We found that the frequency of IL-21-producing CD8+CXCR5+ T cells was higher in HCC tumor tissue than in peritumoral tissue or peripheral blood from the same patients or in blood from healthy donors. Moreover, CD8+CXCR5+ T cells migrated in response to supernatants from primary HCC (HCC-SN) cells, and HCC-SN cells also powerfully induced CXCR5 expression in CD8+ T cells and IL-21 expression in CD8+CXCR5+ T cells. CD8+CXCR5+ T cells from HCC patients, but not those from healthy individuals, stimulated CD19+ B cells to differentiate into IgG-producing plasmablasts. These findings reveal that CD8+CXCR5+ T cells strongly infiltrate HCC tumors, and their infiltration is predictive of a better prognosis. Surprisingly, moreover, CD8+CXCR5+ T cells produced IL-21, which induced B cells to differentiate into IgG-producing plasmablasts and to play a key role in humoral immunity in HCC.
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spelling pubmed-68344252019-11-13 CD8+CXCR5+T cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis Ye, Linsen Li, Yang Tang, Hui Liu, Wei Chen, Yunhao Dai, Tianxing Liang, Rongpu Shi, Mengchen Yi, Shuhong Chen, Guihua Yang, Yang Aging (Albany NY) Research Paper CD8+ T cells are thought to be the primary cytotoxic lymphocytes exerting antitumor effects. However, few studies have focused on the antitumor effects of CD8+ T cell-mediated humoral immunity or on interactions between CD8+ T cells and B cells in hepatocellular carcinoma (HCC). We found that the frequency of IL-21-producing CD8+CXCR5+ T cells was higher in HCC tumor tissue than in peritumoral tissue or peripheral blood from the same patients or in blood from healthy donors. Moreover, CD8+CXCR5+ T cells migrated in response to supernatants from primary HCC (HCC-SN) cells, and HCC-SN cells also powerfully induced CXCR5 expression in CD8+ T cells and IL-21 expression in CD8+CXCR5+ T cells. CD8+CXCR5+ T cells from HCC patients, but not those from healthy individuals, stimulated CD19+ B cells to differentiate into IgG-producing plasmablasts. These findings reveal that CD8+CXCR5+ T cells strongly infiltrate HCC tumors, and their infiltration is predictive of a better prognosis. Surprisingly, moreover, CD8+CXCR5+ T cells produced IL-21, which induced B cells to differentiate into IgG-producing plasmablasts and to play a key role in humoral immunity in HCC. Impact Journals 2019-10-30 /pmc/articles/PMC6834425/ /pubmed/31663864 http://dx.doi.org/10.18632/aging.102308 Text en Copyright © 2019 Ye et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Ye, Linsen
Li, Yang
Tang, Hui
Liu, Wei
Chen, Yunhao
Dai, Tianxing
Liang, Rongpu
Shi, Mengchen
Yi, Shuhong
Chen, Guihua
Yang, Yang
CD8+CXCR5+T cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis
title CD8+CXCR5+T cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis
title_full CD8+CXCR5+T cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis
title_fullStr CD8+CXCR5+T cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis
title_full_unstemmed CD8+CXCR5+T cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis
title_short CD8+CXCR5+T cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis
title_sort cd8+cxcr5+t cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834425/
https://www.ncbi.nlm.nih.gov/pubmed/31663864
http://dx.doi.org/10.18632/aging.102308
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