Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development

Tissue accumulation of p16(INK4a)-positive senescent cells is associated with age-related disorders, such as osteoarthritis (OA). These cell-cycle arrested cells affect tissue function through a specific secretory phenotype. The links between OA onset and senescence remain poorly described. Using ex...

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Detalles Bibliográficos
Autores principales: Malaise, Olivier, Tachikart, Yassin, Constantinides, Michael, Mumme, Marcus, Ferreira-Lopez, Rosanna, Noack, Sandra, Krettek, Christian, Noël, Daniele, Wang, Jing, Jorgensen, Christian, Brondello, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834426/
https://www.ncbi.nlm.nih.gov/pubmed/31644429
http://dx.doi.org/10.18632/aging.102379

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