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Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers
While the majority of all human cancers counteract telomere shortening by expressing telomerase, ~15% of all cancers maintain telomere length by a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). Here, we show that high load of intrinsic DNA damage is present in...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Higher Education Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834538/ https://www.ncbi.nlm.nih.gov/pubmed/31115790 http://dx.doi.org/10.1007/s13238-019-0634-z |