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Surface stabilized atorvastatin nanocrystals with improved bioavailability, safety and antihyperlipidemic potential
Atorvastatin, a favored option for hyperlipidemia exhibits the problem of poor gastric solubility and low absolute bioavailability (12%) along with higher pre-systemic clearance (>80%). Therefore, to circumvent these limitations, atorvastatin nanocrystals were prepared using poloxamer-188 as stab...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834591/ https://www.ncbi.nlm.nih.gov/pubmed/31695118 http://dx.doi.org/10.1038/s41598-019-52645-0 |