An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

The pharmacokinetic properties of antibodies are largely dictated by the pH-dependent binding of the IgG fragment crystallizable (Fc) domain to the human neonatal Fc receptor (hFcRn). Engineered Fc domains that confer a longer circulation half-life by virtue of more favorable pH-dependent binding to...

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Detalles Bibliográficos
Autores principales: Lee, Chang-Han, Kang, Tae Hyun, Godon, Ophélie, Watanabe, Makiko, Delidakis, George, Gillis, Caitlin M., Sterlin, Delphine, Hardy, David, Cogné, Michel, Macdonald, Lynn E., Murphy, Andrew J., Tu, Naxin, Lee, Jiwon, McDaniel, Jonathan R., Makowski, Emily, Tessier, Peter M., Meyer, Aaron S., Bruhns, Pierre, Georgiou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834678/
https://www.ncbi.nlm.nih.gov/pubmed/31695028
http://dx.doi.org/10.1038/s41467-019-13108-2

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