PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages

BACKGROUND: Chronic inflammation has been linked to insulin resistance and type 2 diabetes mellitus (T2DM). High-fat diet (HFD)-derived fatty acid is associated with the activation of chronic inflammation in T2DM. PF-04620110, which is currently in phase 1 clinical trials as a selective acyl-CoA:dia...

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Detalles Bibliográficos
Autores principales: Jo, Seung Il, Bae, Jung Hwan, Kim, Seong Jin, Lee, Jong Min, Jeong, Ji Hun, Moon, Jong-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834844/
https://www.ncbi.nlm.nih.gov/pubmed/31694081
http://dx.doi.org/10.4093/dmj.2019.0112

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