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Heterogeneity in Metabolic Responses to Dietary Fructose

Consumption of fructose has dramatically increased in past few decades in children and adults. Increasing evidence indicates that added sugars (particularly fructose) have adverse effects on metabolism and lead to numerous cardiometabolic diseases. Although both fructose and glucose are components o...

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Autores principales: Hou, Ruixue, Panda, Chinmayee, Voruganti, V. Saroja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834945/
https://www.ncbi.nlm.nih.gov/pubmed/31737029
http://dx.doi.org/10.3389/fgene.2019.00945
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author Hou, Ruixue
Panda, Chinmayee
Voruganti, V. Saroja
author_facet Hou, Ruixue
Panda, Chinmayee
Voruganti, V. Saroja
author_sort Hou, Ruixue
collection PubMed
description Consumption of fructose has dramatically increased in past few decades in children and adults. Increasing evidence indicates that added sugars (particularly fructose) have adverse effects on metabolism and lead to numerous cardiometabolic diseases. Although both fructose and glucose are components of sucrose and high fructose corn syrup, the sugars have different metabolic fates in the human body and the effects of fructose on health are thought to be more adverse than glucose. Studies have also shown that the metabolic effects of fructose differ between individuals based on their genetic background, as individuals with specific SNPs and risk alleles seem to be more susceptible to the adverse metabolic effects of fructose. The current review discusses the metabolic effects of fructose on key complex diseases and discusses the heterogeneity in metabolic responses to dietary fructose in humans.
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spelling pubmed-68349452019-11-15 Heterogeneity in Metabolic Responses to Dietary Fructose Hou, Ruixue Panda, Chinmayee Voruganti, V. Saroja Front Genet Genetics Consumption of fructose has dramatically increased in past few decades in children and adults. Increasing evidence indicates that added sugars (particularly fructose) have adverse effects on metabolism and lead to numerous cardiometabolic diseases. Although both fructose and glucose are components of sucrose and high fructose corn syrup, the sugars have different metabolic fates in the human body and the effects of fructose on health are thought to be more adverse than glucose. Studies have also shown that the metabolic effects of fructose differ between individuals based on their genetic background, as individuals with specific SNPs and risk alleles seem to be more susceptible to the adverse metabolic effects of fructose. The current review discusses the metabolic effects of fructose on key complex diseases and discusses the heterogeneity in metabolic responses to dietary fructose in humans. Frontiers Media S.A. 2019-10-31 /pmc/articles/PMC6834945/ /pubmed/31737029 http://dx.doi.org/10.3389/fgene.2019.00945 Text en Copyright © 2019 Hou, Panda and Voruganti http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Hou, Ruixue
Panda, Chinmayee
Voruganti, V. Saroja
Heterogeneity in Metabolic Responses to Dietary Fructose
title Heterogeneity in Metabolic Responses to Dietary Fructose
title_full Heterogeneity in Metabolic Responses to Dietary Fructose
title_fullStr Heterogeneity in Metabolic Responses to Dietary Fructose
title_full_unstemmed Heterogeneity in Metabolic Responses to Dietary Fructose
title_short Heterogeneity in Metabolic Responses to Dietary Fructose
title_sort heterogeneity in metabolic responses to dietary fructose
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834945/
https://www.ncbi.nlm.nih.gov/pubmed/31737029
http://dx.doi.org/10.3389/fgene.2019.00945
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