Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy

This study evaluated myocardial nuclear staining for the DNA damage markers poly(ADP-ribose) (PAR) and γ-H2A.X in 58 patients with dilated cardiomyopathy. Patients with left ventricular reverse remodeling (LVRR) showed a significantly smaller proportion of PAR-positive nuclei and γ-H2A.X–positive nu...

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Detalles Bibliográficos
Autores principales: Ko, Toshiyuki, Fujita, Kanna, Nomura, Seitaro, Uemura, Yukari, Yamada, Shintaro, Tobita, Takashige, Katoh, Manami, Satoh, Masahiro, Ito, Masamichi, Domoto, Yukako, Hosoya, Yumiko, Amiya, Eisuke, Hatano, Masaru, Morita, Hiroyuki, Fukayama, Masashi, Aburatani, Hiroyuki, Komuro, Issei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834953/
https://www.ncbi.nlm.nih.gov/pubmed/31709317
http://dx.doi.org/10.1016/j.jacbts.2019.05.010
Descripción
Sumario:This study evaluated myocardial nuclear staining for the DNA damage markers poly(ADP-ribose) (PAR) and γ-H2A.X in 58 patients with dilated cardiomyopathy. Patients with left ventricular reverse remodeling (LVRR) showed a significantly smaller proportion of PAR-positive nuclei and γ-H2A.X–positive nuclei in biopsy specimens compared with those without LVRR. Propensity analysis showed that the proportion of both PAR-positive and γ-H2A.X–positive nuclei were independent prognostic factors for LVRR. In conclusion, we showed the utility of DNA damage-marker staining to predict the probability of LVRR, thus revealing a novel prognostic predictor of medical therapy for dilated cardiomyopathy.

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