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Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy
This study evaluated myocardial nuclear staining for the DNA damage markers poly(ADP-ribose) (PAR) and γ-H2A.X in 58 patients with dilated cardiomyopathy. Patients with left ventricular reverse remodeling (LVRR) showed a significantly smaller proportion of PAR-positive nuclei and γ-H2A.X–positive nu...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834953/ https://www.ncbi.nlm.nih.gov/pubmed/31709317 http://dx.doi.org/10.1016/j.jacbts.2019.05.010 |
| _version_ | 1783466568657666048 |
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| author | Ko, Toshiyuki Fujita, Kanna Nomura, Seitaro Uemura, Yukari Yamada, Shintaro Tobita, Takashige Katoh, Manami Satoh, Masahiro Ito, Masamichi Domoto, Yukako Hosoya, Yumiko Amiya, Eisuke Hatano, Masaru Morita, Hiroyuki Fukayama, Masashi Aburatani, Hiroyuki Komuro, Issei |
| author_facet | Ko, Toshiyuki Fujita, Kanna Nomura, Seitaro Uemura, Yukari Yamada, Shintaro Tobita, Takashige Katoh, Manami Satoh, Masahiro Ito, Masamichi Domoto, Yukako Hosoya, Yumiko Amiya, Eisuke Hatano, Masaru Morita, Hiroyuki Fukayama, Masashi Aburatani, Hiroyuki Komuro, Issei |
| author_sort | Ko, Toshiyuki |
| collection | PubMed |
| description | This study evaluated myocardial nuclear staining for the DNA damage markers poly(ADP-ribose) (PAR) and γ-H2A.X in 58 patients with dilated cardiomyopathy. Patients with left ventricular reverse remodeling (LVRR) showed a significantly smaller proportion of PAR-positive nuclei and γ-H2A.X–positive nuclei in biopsy specimens compared with those without LVRR. Propensity analysis showed that the proportion of both PAR-positive and γ-H2A.X–positive nuclei were independent prognostic factors for LVRR. In conclusion, we showed the utility of DNA damage-marker staining to predict the probability of LVRR, thus revealing a novel prognostic predictor of medical therapy for dilated cardiomyopathy. |
| format | Online Article Text |
| id | pubmed-6834953 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68349532019-11-08 Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy Ko, Toshiyuki Fujita, Kanna Nomura, Seitaro Uemura, Yukari Yamada, Shintaro Tobita, Takashige Katoh, Manami Satoh, Masahiro Ito, Masamichi Domoto, Yukako Hosoya, Yumiko Amiya, Eisuke Hatano, Masaru Morita, Hiroyuki Fukayama, Masashi Aburatani, Hiroyuki Komuro, Issei JACC Basic Transl Sci PRECLINICAL RESEARCH This study evaluated myocardial nuclear staining for the DNA damage markers poly(ADP-ribose) (PAR) and γ-H2A.X in 58 patients with dilated cardiomyopathy. Patients with left ventricular reverse remodeling (LVRR) showed a significantly smaller proportion of PAR-positive nuclei and γ-H2A.X–positive nuclei in biopsy specimens compared with those without LVRR. Propensity analysis showed that the proportion of both PAR-positive and γ-H2A.X–positive nuclei were independent prognostic factors for LVRR. In conclusion, we showed the utility of DNA damage-marker staining to predict the probability of LVRR, thus revealing a novel prognostic predictor of medical therapy for dilated cardiomyopathy. Elsevier 2019-09-25 /pmc/articles/PMC6834953/ /pubmed/31709317 http://dx.doi.org/10.1016/j.jacbts.2019.05.010 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | PRECLINICAL RESEARCH Ko, Toshiyuki Fujita, Kanna Nomura, Seitaro Uemura, Yukari Yamada, Shintaro Tobita, Takashige Katoh, Manami Satoh, Masahiro Ito, Masamichi Domoto, Yukako Hosoya, Yumiko Amiya, Eisuke Hatano, Masaru Morita, Hiroyuki Fukayama, Masashi Aburatani, Hiroyuki Komuro, Issei Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy |
| title | Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy |
| title_full | Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy |
| title_fullStr | Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy |
| title_full_unstemmed | Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy |
| title_short | Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy |
| title_sort | quantification of dna damage in heart tissue as a novel prediction tool for therapeutic prognosis of patients with dilated cardiomyopathy |
| topic | PRECLINICAL RESEARCH |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834953/ https://www.ncbi.nlm.nih.gov/pubmed/31709317 http://dx.doi.org/10.1016/j.jacbts.2019.05.010 |
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