Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway

Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells....

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Detalles Bibliográficos
Autores principales: Prud’homme, Mathilde, Coutrot, Maxime, Michel, Thibault, Boutin, Louis, Genest, Magali, Poirier, Françoise, Launay, Jean-Marie, Kane, Bocar, Kinugasa, Satoshi, Prakoura, Niki, Vandermeersch, Sophie, Cohen-Solal, Alain, Delcayre, Claude, Samuel, Jane-Lise, Mehta, Ravindra, Gayat, Etienne, Mebazaa, Alexandre, Chadjichristos, Christos E., Legrand, Matthieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834958/
https://www.ncbi.nlm.nih.gov/pubmed/31709320
http://dx.doi.org/10.1016/j.jacbts.2019.06.005
Descripción
Sumario:Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.

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