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Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells....
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834958/ https://www.ncbi.nlm.nih.gov/pubmed/31709320 http://dx.doi.org/10.1016/j.jacbts.2019.06.005 |
| _version_ | 1783466568886255616 |
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| author | Prud’homme, Mathilde Coutrot, Maxime Michel, Thibault Boutin, Louis Genest, Magali Poirier, Françoise Launay, Jean-Marie Kane, Bocar Kinugasa, Satoshi Prakoura, Niki Vandermeersch, Sophie Cohen-Solal, Alain Delcayre, Claude Samuel, Jane-Lise Mehta, Ravindra Gayat, Etienne Mebazaa, Alexandre Chadjichristos, Christos E. Legrand, Matthieu |
| author_facet | Prud’homme, Mathilde Coutrot, Maxime Michel, Thibault Boutin, Louis Genest, Magali Poirier, Françoise Launay, Jean-Marie Kane, Bocar Kinugasa, Satoshi Prakoura, Niki Vandermeersch, Sophie Cohen-Solal, Alain Delcayre, Claude Samuel, Jane-Lise Mehta, Ravindra Gayat, Etienne Mebazaa, Alexandre Chadjichristos, Christos E. Legrand, Matthieu |
| author_sort | Prud’homme, Mathilde |
| collection | PubMed |
| description | Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway. |
| format | Online Article Text |
| id | pubmed-6834958 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68349582019-11-08 Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway Prud’homme, Mathilde Coutrot, Maxime Michel, Thibault Boutin, Louis Genest, Magali Poirier, Françoise Launay, Jean-Marie Kane, Bocar Kinugasa, Satoshi Prakoura, Niki Vandermeersch, Sophie Cohen-Solal, Alain Delcayre, Claude Samuel, Jane-Lise Mehta, Ravindra Gayat, Etienne Mebazaa, Alexandre Chadjichristos, Christos E. Legrand, Matthieu JACC Basic Transl Sci PRECLINICAL RESEARCH Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway. Elsevier 2019-10-28 /pmc/articles/PMC6834958/ /pubmed/31709320 http://dx.doi.org/10.1016/j.jacbts.2019.06.005 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | PRECLINICAL RESEARCH Prud’homme, Mathilde Coutrot, Maxime Michel, Thibault Boutin, Louis Genest, Magali Poirier, Françoise Launay, Jean-Marie Kane, Bocar Kinugasa, Satoshi Prakoura, Niki Vandermeersch, Sophie Cohen-Solal, Alain Delcayre, Claude Samuel, Jane-Lise Mehta, Ravindra Gayat, Etienne Mebazaa, Alexandre Chadjichristos, Christos E. Legrand, Matthieu Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway |
| title | Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway |
| title_full | Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway |
| title_fullStr | Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway |
| title_full_unstemmed | Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway |
| title_short | Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway |
| title_sort | acute kidney injury induces remote cardiac damage and dysfunction through the galectin-3 pathway |
| topic | PRECLINICAL RESEARCH |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834958/ https://www.ncbi.nlm.nih.gov/pubmed/31709320 http://dx.doi.org/10.1016/j.jacbts.2019.06.005 |
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