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Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway

Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells....

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Autores principales: Prud’homme, Mathilde, Coutrot, Maxime, Michel, Thibault, Boutin, Louis, Genest, Magali, Poirier, Françoise, Launay, Jean-Marie, Kane, Bocar, Kinugasa, Satoshi, Prakoura, Niki, Vandermeersch, Sophie, Cohen-Solal, Alain, Delcayre, Claude, Samuel, Jane-Lise, Mehta, Ravindra, Gayat, Etienne, Mebazaa, Alexandre, Chadjichristos, Christos E., Legrand, Matthieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834958/
https://www.ncbi.nlm.nih.gov/pubmed/31709320
http://dx.doi.org/10.1016/j.jacbts.2019.06.005
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author Prud’homme, Mathilde
Coutrot, Maxime
Michel, Thibault
Boutin, Louis
Genest, Magali
Poirier, Françoise
Launay, Jean-Marie
Kane, Bocar
Kinugasa, Satoshi
Prakoura, Niki
Vandermeersch, Sophie
Cohen-Solal, Alain
Delcayre, Claude
Samuel, Jane-Lise
Mehta, Ravindra
Gayat, Etienne
Mebazaa, Alexandre
Chadjichristos, Christos E.
Legrand, Matthieu
author_facet Prud’homme, Mathilde
Coutrot, Maxime
Michel, Thibault
Boutin, Louis
Genest, Magali
Poirier, Françoise
Launay, Jean-Marie
Kane, Bocar
Kinugasa, Satoshi
Prakoura, Niki
Vandermeersch, Sophie
Cohen-Solal, Alain
Delcayre, Claude
Samuel, Jane-Lise
Mehta, Ravindra
Gayat, Etienne
Mebazaa, Alexandre
Chadjichristos, Christos E.
Legrand, Matthieu
author_sort Prud’homme, Mathilde
collection PubMed
description Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.
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spelling pubmed-68349582019-11-08 Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway Prud’homme, Mathilde Coutrot, Maxime Michel, Thibault Boutin, Louis Genest, Magali Poirier, Françoise Launay, Jean-Marie Kane, Bocar Kinugasa, Satoshi Prakoura, Niki Vandermeersch, Sophie Cohen-Solal, Alain Delcayre, Claude Samuel, Jane-Lise Mehta, Ravindra Gayat, Etienne Mebazaa, Alexandre Chadjichristos, Christos E. Legrand, Matthieu JACC Basic Transl Sci PRECLINICAL RESEARCH Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway. Elsevier 2019-10-28 /pmc/articles/PMC6834958/ /pubmed/31709320 http://dx.doi.org/10.1016/j.jacbts.2019.06.005 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Prud’homme, Mathilde
Coutrot, Maxime
Michel, Thibault
Boutin, Louis
Genest, Magali
Poirier, Françoise
Launay, Jean-Marie
Kane, Bocar
Kinugasa, Satoshi
Prakoura, Niki
Vandermeersch, Sophie
Cohen-Solal, Alain
Delcayre, Claude
Samuel, Jane-Lise
Mehta, Ravindra
Gayat, Etienne
Mebazaa, Alexandre
Chadjichristos, Christos E.
Legrand, Matthieu
Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
title Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
title_full Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
title_fullStr Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
title_full_unstemmed Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
title_short Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
title_sort acute kidney injury induces remote cardiac damage and dysfunction through the galectin-3 pathway
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834958/
https://www.ncbi.nlm.nih.gov/pubmed/31709320
http://dx.doi.org/10.1016/j.jacbts.2019.06.005
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