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Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction
No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic re...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834964/ https://www.ncbi.nlm.nih.gov/pubmed/31709319 http://dx.doi.org/10.1016/j.jacbts.2019.06.001 |
| _version_ | 1783466569898131456 |
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| author | Ide, Yuya Horie, Takahiro Saito, Naritatsu Watanabe, Shin Otani, Chiharu Miyasaka, Yui Kuwabara, Yasuhide Nishino, Tomohiro Nakao, Tetsushi Nishiga, Masataka Nishi, Hitoo Nakashima, Yasuhiro Nakazeki, Fumiko Koyama, Satoshi Kimura, Masahiro Tsuji, Shuhei Rodriguez, Randolph Ruiz Xu, Sijia Yamasaki, Tomohiro Watanabe, Toshimitsu Yamamoto, Masamichi Yanagita, Motoko Kimura, Takeshi Kakizuka, Akira Ono, Koh |
| author_facet | Ide, Yuya Horie, Takahiro Saito, Naritatsu Watanabe, Shin Otani, Chiharu Miyasaka, Yui Kuwabara, Yasuhide Nishino, Tomohiro Nakao, Tetsushi Nishiga, Masataka Nishi, Hitoo Nakashima, Yasuhiro Nakazeki, Fumiko Koyama, Satoshi Kimura, Masahiro Tsuji, Shuhei Rodriguez, Randolph Ruiz Xu, Sijia Yamasaki, Tomohiro Watanabe, Toshimitsu Yamamoto, Masamichi Yanagita, Motoko Kimura, Takeshi Kakizuka, Akira Ono, Koh |
| author_sort | Ide, Yuya |
| collection | PubMed |
| description | No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of KUS121 in a porcine ischemia and reperfusion injury model. These findings confirmed that KUS121 is a promising novel therapeutic agent for myocardial infarction in conjunction with primary percutaneous coronary intervention. |
| format | Online Article Text |
| id | pubmed-6834964 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68349642019-11-08 Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction Ide, Yuya Horie, Takahiro Saito, Naritatsu Watanabe, Shin Otani, Chiharu Miyasaka, Yui Kuwabara, Yasuhide Nishino, Tomohiro Nakao, Tetsushi Nishiga, Masataka Nishi, Hitoo Nakashima, Yasuhiro Nakazeki, Fumiko Koyama, Satoshi Kimura, Masahiro Tsuji, Shuhei Rodriguez, Randolph Ruiz Xu, Sijia Yamasaki, Tomohiro Watanabe, Toshimitsu Yamamoto, Masamichi Yanagita, Motoko Kimura, Takeshi Kakizuka, Akira Ono, Koh JACC Basic Transl Sci PRECLINICAL RESEARCH No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of KUS121 in a porcine ischemia and reperfusion injury model. These findings confirmed that KUS121 is a promising novel therapeutic agent for myocardial infarction in conjunction with primary percutaneous coronary intervention. Elsevier 2019-10-28 /pmc/articles/PMC6834964/ /pubmed/31709319 http://dx.doi.org/10.1016/j.jacbts.2019.06.001 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | PRECLINICAL RESEARCH Ide, Yuya Horie, Takahiro Saito, Naritatsu Watanabe, Shin Otani, Chiharu Miyasaka, Yui Kuwabara, Yasuhide Nishino, Tomohiro Nakao, Tetsushi Nishiga, Masataka Nishi, Hitoo Nakashima, Yasuhiro Nakazeki, Fumiko Koyama, Satoshi Kimura, Masahiro Tsuji, Shuhei Rodriguez, Randolph Ruiz Xu, Sijia Yamasaki, Tomohiro Watanabe, Toshimitsu Yamamoto, Masamichi Yanagita, Motoko Kimura, Takeshi Kakizuka, Akira Ono, Koh Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction |
| title | Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction |
| title_full | Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction |
| title_fullStr | Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction |
| title_full_unstemmed | Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction |
| title_short | Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction |
| title_sort | cardioprotective effects of vcp modulator kus121 in murine and porcine models of myocardial infarction |
| topic | PRECLINICAL RESEARCH |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834964/ https://www.ncbi.nlm.nih.gov/pubmed/31709319 http://dx.doi.org/10.1016/j.jacbts.2019.06.001 |
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