The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer

CULLIN3‐based E3 ubiquitin ligase substrate‐binding adaptor gene SPOP is frequently mutated in prostate cancer (PCa). PCa harboring SPOP hotspot mutants (e.g., F133V) are resistant to BET inhibitors because of aberrant elevation of BET proteins. Here, we identified a previously unrecognized mutation...

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Detalles Bibliográficos
Autores principales: Yan, Yuqian, Ma, Jian, Wang, Dejie, Lin, Dong, Pang, Xiaodong, Wang, Shangqian, Zhao, Yu, Shi, Lei, Xue, Hui, Pan, Yunqian, Zhang, Jun, Wahlestedt, Claes, Giles, Francis J, Chen, Yu, Gleave, Martin E, Collins, Collin C, Ye, Dingwei, Wang, Yuzhuo, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835201/
https://www.ncbi.nlm.nih.gov/pubmed/31559706
http://dx.doi.org/10.15252/emmm.201910659

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