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Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques

Today, efficient delivery of sorafenib to hepatocellular carcinoma remains a challenge for current drug formulation strategies. Incorporating the lipophilic molecule into biocompatible and biodegradable theranostic nanocarriers has great potential for improving the efficacy and safety of cancer ther...

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Autores principales: Feczkó, Tivadar, Piiper, Albrecht, Pleli, Thomas, Schmithals, Christian, Denk, Dominic, Hehlgans, Stephanie, Rödel, Franz, Vogl, Thomas J., Wacker, Matthias G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835296/
https://www.ncbi.nlm.nih.gov/pubmed/31548500
http://dx.doi.org/10.3390/pharmaceutics11100489
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author Feczkó, Tivadar
Piiper, Albrecht
Pleli, Thomas
Schmithals, Christian
Denk, Dominic
Hehlgans, Stephanie
Rödel, Franz
Vogl, Thomas J.
Wacker, Matthias G.
author_facet Feczkó, Tivadar
Piiper, Albrecht
Pleli, Thomas
Schmithals, Christian
Denk, Dominic
Hehlgans, Stephanie
Rödel, Franz
Vogl, Thomas J.
Wacker, Matthias G.
author_sort Feczkó, Tivadar
collection PubMed
description Today, efficient delivery of sorafenib to hepatocellular carcinoma remains a challenge for current drug formulation strategies. Incorporating the lipophilic molecule into biocompatible and biodegradable theranostic nanocarriers has great potential for improving the efficacy and safety of cancer therapy. In the present study, three different technologies for the encapsulation of sorafenib into poly(d,l-lactide-co-glycolide) and polyethylene glycol-poly(d,l-lactide-co-glycolide) copolymers were compared. The particles ranged in size between 220 and 240 nm, with encapsulation efficiencies from 76.1 ± 1.7% to 69.1 ± 10.1%. A remarkable maximum drug load of approximately 9.0% was achieved. Finally, a gadolinium complex was covalently attached to the nanoparticle surface, transforming the nanospheres into theranostic devices, allowing their localization using magnetic resonance imaging. The manufacture of sorafenib-loaded nanoparticles alongside the functionalization of the particle surface with gadolinium complexes resulted in a highly efficacious nanodelivery system which exhibited a strong magnetic resonance imaging signal, optimal stability features, and a sustained release profile.
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spelling pubmed-68352962019-11-25 Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques Feczkó, Tivadar Piiper, Albrecht Pleli, Thomas Schmithals, Christian Denk, Dominic Hehlgans, Stephanie Rödel, Franz Vogl, Thomas J. Wacker, Matthias G. Pharmaceutics Article Today, efficient delivery of sorafenib to hepatocellular carcinoma remains a challenge for current drug formulation strategies. Incorporating the lipophilic molecule into biocompatible and biodegradable theranostic nanocarriers has great potential for improving the efficacy and safety of cancer therapy. In the present study, three different technologies for the encapsulation of sorafenib into poly(d,l-lactide-co-glycolide) and polyethylene glycol-poly(d,l-lactide-co-glycolide) copolymers were compared. The particles ranged in size between 220 and 240 nm, with encapsulation efficiencies from 76.1 ± 1.7% to 69.1 ± 10.1%. A remarkable maximum drug load of approximately 9.0% was achieved. Finally, a gadolinium complex was covalently attached to the nanoparticle surface, transforming the nanospheres into theranostic devices, allowing their localization using magnetic resonance imaging. The manufacture of sorafenib-loaded nanoparticles alongside the functionalization of the particle surface with gadolinium complexes resulted in a highly efficacious nanodelivery system which exhibited a strong magnetic resonance imaging signal, optimal stability features, and a sustained release profile. MDPI 2019-09-23 /pmc/articles/PMC6835296/ /pubmed/31548500 http://dx.doi.org/10.3390/pharmaceutics11100489 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Feczkó, Tivadar
Piiper, Albrecht
Pleli, Thomas
Schmithals, Christian
Denk, Dominic
Hehlgans, Stephanie
Rödel, Franz
Vogl, Thomas J.
Wacker, Matthias G.
Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques
title Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques
title_full Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques
title_fullStr Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques
title_full_unstemmed Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques
title_short Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques
title_sort theranostic sorafenib-loaded polymeric nanocarriers manufactured by enhanced gadolinium conjugation techniques
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835296/
https://www.ncbi.nlm.nih.gov/pubmed/31548500
http://dx.doi.org/10.3390/pharmaceutics11100489
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