Cargando…

Circulating Folate Concentrations and Risk of Peripheral Neuropathy and Mortality: A Retrospective Cohort Study in the U.K

Background: Folate deficiency may increase the risk of peripheral neuropathy but there is a paucity of data from large prospective studies examining this association. Methods: Longitudinal analysis of electronic health records in The Health Improvement Network (THIN), a U.K. primary care database in...

Descripción completa

Detalles Bibliográficos
Autores principales: Taverner, Tom, Crowe, Francesca L., Thomas, G. Neil, Gokhale, Krishna, Thayakaran, Rasiah, Nirantharakumar, Krishnarajah, Rajabally, Yusuf A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835340/
https://www.ncbi.nlm.nih.gov/pubmed/31614995
http://dx.doi.org/10.3390/nu11102443
_version_ 1783466649314131968
author Taverner, Tom
Crowe, Francesca L.
Thomas, G. Neil
Gokhale, Krishna
Thayakaran, Rasiah
Nirantharakumar, Krishnarajah
Rajabally, Yusuf A.
author_facet Taverner, Tom
Crowe, Francesca L.
Thomas, G. Neil
Gokhale, Krishna
Thayakaran, Rasiah
Nirantharakumar, Krishnarajah
Rajabally, Yusuf A.
author_sort Taverner, Tom
collection PubMed
description Background: Folate deficiency may increase the risk of peripheral neuropathy but there is a paucity of data from large prospective studies examining this association. Methods: Longitudinal analysis of electronic health records in The Health Improvement Network (THIN), a U.K. primary care database including 594,338 patients aged 18–70 years with a folate measurement and without a history of peripheral neuropathy. Results: After a mean follow-up of 3.71 (standard deviation (SD) = 3.14) years, 1949 patients were diagnosed with peripheral neuropathy and 20,679 patients died. In those <40 years, compared to patients with folate ≥13.6 nmol/L, those with folate <6.8 (deficient) and 6.8–13.5 nmol/L (insufficient) had a hazard ratio (HR) for peripheral neuropathy of 1.83 (95% confidence intervals (CI) = 1.16–2.91) and 1.48 (95% CI = 1.04–2.08), respectively. There was no significant association between folate and peripheral neuropathy among those aged 41–70 years. Compared to patients with folate ≥ 13.6 nmol/L, folate <6.8 nmol/L was associated with a greater risk of death among all ages. Conclusion: Folate deficiency and insufficiency was associated with a greater risk of peripheral neuropathy among younger patients. This investigation should be replicated in other large datasets and it may be important to monitor peripheral neuropathy incidence after the introduction of mandatory folic acid fortification of flour in the U.K.
format Online
Article
Text
id pubmed-6835340
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-68353402019-11-25 Circulating Folate Concentrations and Risk of Peripheral Neuropathy and Mortality: A Retrospective Cohort Study in the U.K Taverner, Tom Crowe, Francesca L. Thomas, G. Neil Gokhale, Krishna Thayakaran, Rasiah Nirantharakumar, Krishnarajah Rajabally, Yusuf A. Nutrients Article Background: Folate deficiency may increase the risk of peripheral neuropathy but there is a paucity of data from large prospective studies examining this association. Methods: Longitudinal analysis of electronic health records in The Health Improvement Network (THIN), a U.K. primary care database including 594,338 patients aged 18–70 years with a folate measurement and without a history of peripheral neuropathy. Results: After a mean follow-up of 3.71 (standard deviation (SD) = 3.14) years, 1949 patients were diagnosed with peripheral neuropathy and 20,679 patients died. In those <40 years, compared to patients with folate ≥13.6 nmol/L, those with folate <6.8 (deficient) and 6.8–13.5 nmol/L (insufficient) had a hazard ratio (HR) for peripheral neuropathy of 1.83 (95% confidence intervals (CI) = 1.16–2.91) and 1.48 (95% CI = 1.04–2.08), respectively. There was no significant association between folate and peripheral neuropathy among those aged 41–70 years. Compared to patients with folate ≥ 13.6 nmol/L, folate <6.8 nmol/L was associated with a greater risk of death among all ages. Conclusion: Folate deficiency and insufficiency was associated with a greater risk of peripheral neuropathy among younger patients. This investigation should be replicated in other large datasets and it may be important to monitor peripheral neuropathy incidence after the introduction of mandatory folic acid fortification of flour in the U.K. MDPI 2019-10-14 /pmc/articles/PMC6835340/ /pubmed/31614995 http://dx.doi.org/10.3390/nu11102443 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Taverner, Tom
Crowe, Francesca L.
Thomas, G. Neil
Gokhale, Krishna
Thayakaran, Rasiah
Nirantharakumar, Krishnarajah
Rajabally, Yusuf A.
Circulating Folate Concentrations and Risk of Peripheral Neuropathy and Mortality: A Retrospective Cohort Study in the U.K
title Circulating Folate Concentrations and Risk of Peripheral Neuropathy and Mortality: A Retrospective Cohort Study in the U.K
title_full Circulating Folate Concentrations and Risk of Peripheral Neuropathy and Mortality: A Retrospective Cohort Study in the U.K
title_fullStr Circulating Folate Concentrations and Risk of Peripheral Neuropathy and Mortality: A Retrospective Cohort Study in the U.K
title_full_unstemmed Circulating Folate Concentrations and Risk of Peripheral Neuropathy and Mortality: A Retrospective Cohort Study in the U.K
title_short Circulating Folate Concentrations and Risk of Peripheral Neuropathy and Mortality: A Retrospective Cohort Study in the U.K
title_sort circulating folate concentrations and risk of peripheral neuropathy and mortality: a retrospective cohort study in the u.k
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835340/
https://www.ncbi.nlm.nih.gov/pubmed/31614995
http://dx.doi.org/10.3390/nu11102443
work_keys_str_mv AT tavernertom circulatingfolateconcentrationsandriskofperipheralneuropathyandmortalityaretrospectivecohortstudyintheuk
AT crowefrancescal circulatingfolateconcentrationsandriskofperipheralneuropathyandmortalityaretrospectivecohortstudyintheuk
AT thomasgneil circulatingfolateconcentrationsandriskofperipheralneuropathyandmortalityaretrospectivecohortstudyintheuk
AT gokhalekrishna circulatingfolateconcentrationsandriskofperipheralneuropathyandmortalityaretrospectivecohortstudyintheuk
AT thayakaranrasiah circulatingfolateconcentrationsandriskofperipheralneuropathyandmortalityaretrospectivecohortstudyintheuk
AT nirantharakumarkrishnarajah circulatingfolateconcentrationsandriskofperipheralneuropathyandmortalityaretrospectivecohortstudyintheuk
AT rajaballyyusufa circulatingfolateconcentrationsandriskofperipheralneuropathyandmortalityaretrospectivecohortstudyintheuk