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Spray Drying of a Subcritical Extract Using Marrubium vulgare as a Method of Choice for Obtaining High Quality Powder

White horehound (Marrubium vulgare L.), is a grey-leaved perennial herb, belonging to Lamiaceae family, distributed in Eurasia and northern Africa. Despite the fact that M. vulgare has been used since ancient times in treating diverse diseases, it is only in the last decade or so that scientists hav...

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Autores principales: Gavarić, Aleksandra, Vladić, Jelena, Ambrus, Rita, Jokić, Stela, Szabó-Révész, Piroska, Tomić, Milan, Blažić, Marijana, Vidović, Senka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835533/
https://www.ncbi.nlm.nih.gov/pubmed/31614551
http://dx.doi.org/10.3390/pharmaceutics11100523
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author Gavarić, Aleksandra
Vladić, Jelena
Ambrus, Rita
Jokić, Stela
Szabó-Révész, Piroska
Tomić, Milan
Blažić, Marijana
Vidović, Senka
author_facet Gavarić, Aleksandra
Vladić, Jelena
Ambrus, Rita
Jokić, Stela
Szabó-Révész, Piroska
Tomić, Milan
Blažić, Marijana
Vidović, Senka
author_sort Gavarić, Aleksandra
collection PubMed
description White horehound (Marrubium vulgare L.), is a grey-leaved perennial herb, belonging to Lamiaceae family, distributed in Eurasia and northern Africa. Despite the fact that M. vulgare has been used since ancient times in treating diverse diseases, it is only in the last decade or so that scientists have been able to lay the foundation for its potential pharmacological actions from the results observed through the prism of ethnopharmacological use of this species. The novelty of this study was that subcritical water extraction, acknowledged as a powerful extraction technology to recover phenolic compounds, was coupled with spray drying. The subcritical horehound extract, obtained using optimal process parameters, was used as a liquid feed in spray drying. Maltodextrin was used as a carrier in a concentration of 10%. Thus, two M. vulgare powders, carrier-free and 10% MD, were produced. Comprehensive powders characterization was conducted in order to evaluate their quality. Results confirmed that spray drying can be used as a method of choice for obtaining high quality horehound powders which kept the amorphous structure constant after 6 months.
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spelling pubmed-68355332019-11-25 Spray Drying of a Subcritical Extract Using Marrubium vulgare as a Method of Choice for Obtaining High Quality Powder Gavarić, Aleksandra Vladić, Jelena Ambrus, Rita Jokić, Stela Szabó-Révész, Piroska Tomić, Milan Blažić, Marijana Vidović, Senka Pharmaceutics Article White horehound (Marrubium vulgare L.), is a grey-leaved perennial herb, belonging to Lamiaceae family, distributed in Eurasia and northern Africa. Despite the fact that M. vulgare has been used since ancient times in treating diverse diseases, it is only in the last decade or so that scientists have been able to lay the foundation for its potential pharmacological actions from the results observed through the prism of ethnopharmacological use of this species. The novelty of this study was that subcritical water extraction, acknowledged as a powerful extraction technology to recover phenolic compounds, was coupled with spray drying. The subcritical horehound extract, obtained using optimal process parameters, was used as a liquid feed in spray drying. Maltodextrin was used as a carrier in a concentration of 10%. Thus, two M. vulgare powders, carrier-free and 10% MD, were produced. Comprehensive powders characterization was conducted in order to evaluate their quality. Results confirmed that spray drying can be used as a method of choice for obtaining high quality horehound powders which kept the amorphous structure constant after 6 months. MDPI 2019-10-11 /pmc/articles/PMC6835533/ /pubmed/31614551 http://dx.doi.org/10.3390/pharmaceutics11100523 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gavarić, Aleksandra
Vladić, Jelena
Ambrus, Rita
Jokić, Stela
Szabó-Révész, Piroska
Tomić, Milan
Blažić, Marijana
Vidović, Senka
Spray Drying of a Subcritical Extract Using Marrubium vulgare as a Method of Choice for Obtaining High Quality Powder
title Spray Drying of a Subcritical Extract Using Marrubium vulgare as a Method of Choice for Obtaining High Quality Powder
title_full Spray Drying of a Subcritical Extract Using Marrubium vulgare as a Method of Choice for Obtaining High Quality Powder
title_fullStr Spray Drying of a Subcritical Extract Using Marrubium vulgare as a Method of Choice for Obtaining High Quality Powder
title_full_unstemmed Spray Drying of a Subcritical Extract Using Marrubium vulgare as a Method of Choice for Obtaining High Quality Powder
title_short Spray Drying of a Subcritical Extract Using Marrubium vulgare as a Method of Choice for Obtaining High Quality Powder
title_sort spray drying of a subcritical extract using marrubium vulgare as a method of choice for obtaining high quality powder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835533/
https://www.ncbi.nlm.nih.gov/pubmed/31614551
http://dx.doi.org/10.3390/pharmaceutics11100523
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