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Search and Selection of Probiotics That Improve Mucositis Symptoms in Oncologic Patients. A Systematic Review

Mucositis is a common and severe adverse effect of radiotherapy and/or chemotherapy treatments applied to oncologic patients. The development of effective therapies and adjuvant treatments to increase their efficacy and reduce adverse effect is a priority in cancer therapy. Probiotics are non-pathog...

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Autores principales: Picó-Monllor, José Antonio, Mingot-Ascencao, José Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835542/
https://www.ncbi.nlm.nih.gov/pubmed/31581434
http://dx.doi.org/10.3390/nu11102322
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author Picó-Monllor, José Antonio
Mingot-Ascencao, José Manuel
author_facet Picó-Monllor, José Antonio
Mingot-Ascencao, José Manuel
author_sort Picó-Monllor, José Antonio
collection PubMed
description Mucositis is a common and severe adverse effect of radiotherapy and/or chemotherapy treatments applied to oncologic patients. The development of effective therapies and adjuvant treatments to increase their efficacy and reduce adverse effect is a priority in cancer therapy. Probiotics are non-pathogenic live microorganisms that when ingested in adequate amounts can colonize the intestinal tract promoting the restoration of a healthy gut microbiota and contributing to all its functions including the maintenance of the integrity of the mucosa and the modulation of the immune system. In order to check the possible efficacy and safety of these microorganisms to prevent or ameliorate mucositis′ symptoms, we have systematically searched the bibliographic databases MEDLINE (via Pubmed), EMBASE, The Cochrane library, Scopus, Web of science, and Latin American and Caribbean Literature in Health of Sciences (LILACS) using the descriptors “Mucositis”, “Probiotics”, “Neoplasms”, “Humans”, and “Clinical Trials”. After applying our inclusion and exclusion criteria, 15 studies were accepted for review and critical analysis. Our analysis suggests that a combination of Bifidobacterium longum, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium infantis, and Saccharomyces boulardii could be a good combination of probiotics to reduce incident rates of mucositis or ameliorate its symptoms in chemo or radiotherapy treated patients.
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spelling pubmed-68355422019-11-25 Search and Selection of Probiotics That Improve Mucositis Symptoms in Oncologic Patients. A Systematic Review Picó-Monllor, José Antonio Mingot-Ascencao, José Manuel Nutrients Review Mucositis is a common and severe adverse effect of radiotherapy and/or chemotherapy treatments applied to oncologic patients. The development of effective therapies and adjuvant treatments to increase their efficacy and reduce adverse effect is a priority in cancer therapy. Probiotics are non-pathogenic live microorganisms that when ingested in adequate amounts can colonize the intestinal tract promoting the restoration of a healthy gut microbiota and contributing to all its functions including the maintenance of the integrity of the mucosa and the modulation of the immune system. In order to check the possible efficacy and safety of these microorganisms to prevent or ameliorate mucositis′ symptoms, we have systematically searched the bibliographic databases MEDLINE (via Pubmed), EMBASE, The Cochrane library, Scopus, Web of science, and Latin American and Caribbean Literature in Health of Sciences (LILACS) using the descriptors “Mucositis”, “Probiotics”, “Neoplasms”, “Humans”, and “Clinical Trials”. After applying our inclusion and exclusion criteria, 15 studies were accepted for review and critical analysis. Our analysis suggests that a combination of Bifidobacterium longum, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium infantis, and Saccharomyces boulardii could be a good combination of probiotics to reduce incident rates of mucositis or ameliorate its symptoms in chemo or radiotherapy treated patients. MDPI 2019-10-01 /pmc/articles/PMC6835542/ /pubmed/31581434 http://dx.doi.org/10.3390/nu11102322 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Picó-Monllor, José Antonio
Mingot-Ascencao, José Manuel
Search and Selection of Probiotics That Improve Mucositis Symptoms in Oncologic Patients. A Systematic Review
title Search and Selection of Probiotics That Improve Mucositis Symptoms in Oncologic Patients. A Systematic Review
title_full Search and Selection of Probiotics That Improve Mucositis Symptoms in Oncologic Patients. A Systematic Review
title_fullStr Search and Selection of Probiotics That Improve Mucositis Symptoms in Oncologic Patients. A Systematic Review
title_full_unstemmed Search and Selection of Probiotics That Improve Mucositis Symptoms in Oncologic Patients. A Systematic Review
title_short Search and Selection of Probiotics That Improve Mucositis Symptoms in Oncologic Patients. A Systematic Review
title_sort search and selection of probiotics that improve mucositis symptoms in oncologic patients. a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835542/
https://www.ncbi.nlm.nih.gov/pubmed/31581434
http://dx.doi.org/10.3390/nu11102322
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