Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus

Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The stru...

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Detalles Bibliográficos
Autores principales: Yurchenko, Anton N., Trinh, Phan Thi Hoai, Girich (Ivanets), Elena V., Smetanina, Olga F., Rasin, Anton B., Popov, Roman S., Dyshlovoy, Sergey A., von Amsberg, Gunhild, Menchinskaya, Ekaterina S., Thanh Van, Tran Thi, Afiyatullov, Shamil Sh.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835654/
https://www.ncbi.nlm.nih.gov/pubmed/31614563
http://dx.doi.org/10.3390/md17100579
Descripción
Sumario:Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The structures of compounds 1–10 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher’s method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells.

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