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Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications
Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga Bifurcaria bifurcata, due to their abundance in bi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835738/ https://www.ncbi.nlm.nih.gov/pubmed/31569367 http://dx.doi.org/10.3390/md17100556 |
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author | Pais, Adriana C.S. Saraiva, Jorge A. Rocha, Sílvia M. Silvestre, Armando J.D. Santos, Sónia A.O. |
author_facet | Pais, Adriana C.S. Saraiva, Jorge A. Rocha, Sílvia M. Silvestre, Armando J.D. Santos, Sónia A.O. |
author_sort | Pais, Adriana C.S. |
collection | PubMed |
description | Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga Bifurcaria bifurcata, due to their abundance in bioactive linear diterpenes. In this appraisal, a thorough review concerning the methodologies used in the extraction, fractionation, and identification of diterpenes from B. bifurcata is provided and discussed in detail. An exhaustive compilation of the mass spectra and nuclear magnetic resonance (NMR) data are also provided. The in vitro and in chemico assays already performed to assess different biological activities attributed to B. bifurcata diterpenes are also reviewed, emphasizing the use of isolated components, enriched fractions, or crude extracts. The associated major strengths and challenges for the exploitation of B. bifurcata diterpenes for high-value applications are critically discussed. |
format | Online Article Text |
id | pubmed-6835738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68357382019-11-25 Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications Pais, Adriana C.S. Saraiva, Jorge A. Rocha, Sílvia M. Silvestre, Armando J.D. Santos, Sónia A.O. Mar Drugs Review Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga Bifurcaria bifurcata, due to their abundance in bioactive linear diterpenes. In this appraisal, a thorough review concerning the methodologies used in the extraction, fractionation, and identification of diterpenes from B. bifurcata is provided and discussed in detail. An exhaustive compilation of the mass spectra and nuclear magnetic resonance (NMR) data are also provided. The in vitro and in chemico assays already performed to assess different biological activities attributed to B. bifurcata diterpenes are also reviewed, emphasizing the use of isolated components, enriched fractions, or crude extracts. The associated major strengths and challenges for the exploitation of B. bifurcata diterpenes for high-value applications are critically discussed. MDPI 2019-09-28 /pmc/articles/PMC6835738/ /pubmed/31569367 http://dx.doi.org/10.3390/md17100556 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pais, Adriana C.S. Saraiva, Jorge A. Rocha, Sílvia M. Silvestre, Armando J.D. Santos, Sónia A.O. Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications |
title | Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications |
title_full | Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications |
title_fullStr | Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications |
title_full_unstemmed | Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications |
title_short | Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications |
title_sort | current research on the bioprospection of linear diterpenes from bifurcaria bifurcata: from extraction methodologies to possible applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835738/ https://www.ncbi.nlm.nih.gov/pubmed/31569367 http://dx.doi.org/10.3390/md17100556 |
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