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The Effectiveness of Different Doses of Iron Supplementation and the Prenatal Determinants of Maternal Iron Status in Pregnant Spanish Women: ECLIPSES Study

Iron deficiency (ID), anemia, iron deficiency anemia (IDA) and excess iron (hemoconcentration) harm maternal–fetal health. We evaluated the effectiveness of different doses of iron supplementation adjusted for the initial levels of hemoglobin (Hb) on maternal iron status and described some associate...

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Autores principales: Iglesias Vázquez, Lucía, Arija, Victoria, Aranda, Núria, Aparicio, Estefanía, Serrat, Núria, Fargas, Francesc, Ruiz, Francisca, Pallejà, Meritxell, Coronel, Pilar, Gimeno, Mercedes, Basora, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835785/
https://www.ncbi.nlm.nih.gov/pubmed/31658725
http://dx.doi.org/10.3390/nu11102418
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author Iglesias Vázquez, Lucía
Arija, Victoria
Aranda, Núria
Aparicio, Estefanía
Serrat, Núria
Fargas, Francesc
Ruiz, Francisca
Pallejà, Meritxell
Coronel, Pilar
Gimeno, Mercedes
Basora, Josep
author_facet Iglesias Vázquez, Lucía
Arija, Victoria
Aranda, Núria
Aparicio, Estefanía
Serrat, Núria
Fargas, Francesc
Ruiz, Francisca
Pallejà, Meritxell
Coronel, Pilar
Gimeno, Mercedes
Basora, Josep
author_sort Iglesias Vázquez, Lucía
collection PubMed
description Iron deficiency (ID), anemia, iron deficiency anemia (IDA) and excess iron (hemoconcentration) harm maternal–fetal health. We evaluated the effectiveness of different doses of iron supplementation adjusted for the initial levels of hemoglobin (Hb) on maternal iron status and described some associated prenatal determinants. The ECLIPSES study included 791 women, randomized into two groups: Stratum 1 (Hb = 110–130g/L, received 40 or 80mg iron daily) and Stratum 2 (Hb > 130g/L, received 20 or 40mg iron daily). Clinical, biochemical, and genetic information was collected during pregnancy, as were lifestyle and sociodemographic characteristics. In Stratum 1, using 80 mg/d instead of 40 mg/d protected against ID on week 36. Only women with ID on week 12 benefited from the protection against anemia and IDA by increasing Hb levels. In Stratum 2, using 20 mg/d instead of 40 mg/d reduced the risk of hemoconcentration in women with initial serum ferritin (SF) ≥ 15 μg/L, while 40 mg/d improved SF levels on week 36 in women with ID in early pregnancy. Mutations in the HFE gene increased the risk of hemoconcentration. Iron supplementation should be adjusted to early pregnancy levels of Hb and iron stores. Mutations of the HFE gene should be evaluated in women with high Hb levels in early pregnancy.
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spelling pubmed-68357852019-11-25 The Effectiveness of Different Doses of Iron Supplementation and the Prenatal Determinants of Maternal Iron Status in Pregnant Spanish Women: ECLIPSES Study Iglesias Vázquez, Lucía Arija, Victoria Aranda, Núria Aparicio, Estefanía Serrat, Núria Fargas, Francesc Ruiz, Francisca Pallejà, Meritxell Coronel, Pilar Gimeno, Mercedes Basora, Josep Nutrients Article Iron deficiency (ID), anemia, iron deficiency anemia (IDA) and excess iron (hemoconcentration) harm maternal–fetal health. We evaluated the effectiveness of different doses of iron supplementation adjusted for the initial levels of hemoglobin (Hb) on maternal iron status and described some associated prenatal determinants. The ECLIPSES study included 791 women, randomized into two groups: Stratum 1 (Hb = 110–130g/L, received 40 or 80mg iron daily) and Stratum 2 (Hb > 130g/L, received 20 or 40mg iron daily). Clinical, biochemical, and genetic information was collected during pregnancy, as were lifestyle and sociodemographic characteristics. In Stratum 1, using 80 mg/d instead of 40 mg/d protected against ID on week 36. Only women with ID on week 12 benefited from the protection against anemia and IDA by increasing Hb levels. In Stratum 2, using 20 mg/d instead of 40 mg/d reduced the risk of hemoconcentration in women with initial serum ferritin (SF) ≥ 15 μg/L, while 40 mg/d improved SF levels on week 36 in women with ID in early pregnancy. Mutations in the HFE gene increased the risk of hemoconcentration. Iron supplementation should be adjusted to early pregnancy levels of Hb and iron stores. Mutations of the HFE gene should be evaluated in women with high Hb levels in early pregnancy. MDPI 2019-10-10 /pmc/articles/PMC6835785/ /pubmed/31658725 http://dx.doi.org/10.3390/nu11102418 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iglesias Vázquez, Lucía
Arija, Victoria
Aranda, Núria
Aparicio, Estefanía
Serrat, Núria
Fargas, Francesc
Ruiz, Francisca
Pallejà, Meritxell
Coronel, Pilar
Gimeno, Mercedes
Basora, Josep
The Effectiveness of Different Doses of Iron Supplementation and the Prenatal Determinants of Maternal Iron Status in Pregnant Spanish Women: ECLIPSES Study
title The Effectiveness of Different Doses of Iron Supplementation and the Prenatal Determinants of Maternal Iron Status in Pregnant Spanish Women: ECLIPSES Study
title_full The Effectiveness of Different Doses of Iron Supplementation and the Prenatal Determinants of Maternal Iron Status in Pregnant Spanish Women: ECLIPSES Study
title_fullStr The Effectiveness of Different Doses of Iron Supplementation and the Prenatal Determinants of Maternal Iron Status in Pregnant Spanish Women: ECLIPSES Study
title_full_unstemmed The Effectiveness of Different Doses of Iron Supplementation and the Prenatal Determinants of Maternal Iron Status in Pregnant Spanish Women: ECLIPSES Study
title_short The Effectiveness of Different Doses of Iron Supplementation and the Prenatal Determinants of Maternal Iron Status in Pregnant Spanish Women: ECLIPSES Study
title_sort effectiveness of different doses of iron supplementation and the prenatal determinants of maternal iron status in pregnant spanish women: eclipses study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835785/
https://www.ncbi.nlm.nih.gov/pubmed/31658725
http://dx.doi.org/10.3390/nu11102418
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