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Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity

The preservation of muscle mass and muscle function after weight loss therapy is currently a considerable challenge in the fight against obesity. Muscle mass secretes proteins called myokines that have relevant functions in the regulation of metabolism and health. This study was aimed to evaluate wh...

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Autores principales: Sajoux, Ignacio, Lorenzo, Paula M., Gomez-Arbelaez, Diego, Zulet, M. Angeles, Abete, Itziar, Castro, Ana I., Baltar, Javier, Portillo, María P., Tinahones, Francisco J., Martinez, J. Alfredo, Crujeiras, Ana B., Casanueva, Felipe F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835835/
https://www.ncbi.nlm.nih.gov/pubmed/31590286
http://dx.doi.org/10.3390/nu11102368
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author Sajoux, Ignacio
Lorenzo, Paula M.
Gomez-Arbelaez, Diego
Zulet, M. Angeles
Abete, Itziar
Castro, Ana I.
Baltar, Javier
Portillo, María P.
Tinahones, Francisco J.
Martinez, J. Alfredo
Crujeiras, Ana B.
Casanueva, Felipe F.
author_facet Sajoux, Ignacio
Lorenzo, Paula M.
Gomez-Arbelaez, Diego
Zulet, M. Angeles
Abete, Itziar
Castro, Ana I.
Baltar, Javier
Portillo, María P.
Tinahones, Francisco J.
Martinez, J. Alfredo
Crujeiras, Ana B.
Casanueva, Felipe F.
author_sort Sajoux, Ignacio
collection PubMed
description The preservation of muscle mass and muscle function after weight loss therapy is currently a considerable challenge in the fight against obesity. Muscle mass secretes proteins called myokines that have relevant functions in the regulation of metabolism and health. This study was aimed to evaluate whether a very low-calorie ketogenic (VLCK) diet may modulate myokine levels, in addition to changes in body composition, compared to a standard, balanced low-calorie (LC) diet or bariatric surgery in patients with obesity. Body composition, ketosis, insulin sensitivity and myokines were evaluated in 79 patients with overweight/obesity after a therapy to lose weight with a VLCK diet, a LC diet or bariatric surgery. The follow-up was 6 months. The weight loss therapies induced changes in myokine levels in association with changes in body composition and biochemical parameters. The effects on circulating myokine levels compared to those at baseline were stronger after the VLCK diet than LC diet or bariatric surgery. Differences reached statistical significance for IL-8, MMP2 and irisin. In conclusion, nutritional interventions or bariatric surgery to lose weight induces changes in circulating myokine levels, being this effect potentially most notable after following a VLCK diet.
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spelling pubmed-68358352019-11-25 Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity Sajoux, Ignacio Lorenzo, Paula M. Gomez-Arbelaez, Diego Zulet, M. Angeles Abete, Itziar Castro, Ana I. Baltar, Javier Portillo, María P. Tinahones, Francisco J. Martinez, J. Alfredo Crujeiras, Ana B. Casanueva, Felipe F. Nutrients Article The preservation of muscle mass and muscle function after weight loss therapy is currently a considerable challenge in the fight against obesity. Muscle mass secretes proteins called myokines that have relevant functions in the regulation of metabolism and health. This study was aimed to evaluate whether a very low-calorie ketogenic (VLCK) diet may modulate myokine levels, in addition to changes in body composition, compared to a standard, balanced low-calorie (LC) diet or bariatric surgery in patients with obesity. Body composition, ketosis, insulin sensitivity and myokines were evaluated in 79 patients with overweight/obesity after a therapy to lose weight with a VLCK diet, a LC diet or bariatric surgery. The follow-up was 6 months. The weight loss therapies induced changes in myokine levels in association with changes in body composition and biochemical parameters. The effects on circulating myokine levels compared to those at baseline were stronger after the VLCK diet than LC diet or bariatric surgery. Differences reached statistical significance for IL-8, MMP2 and irisin. In conclusion, nutritional interventions or bariatric surgery to lose weight induces changes in circulating myokine levels, being this effect potentially most notable after following a VLCK diet. MDPI 2019-10-04 /pmc/articles/PMC6835835/ /pubmed/31590286 http://dx.doi.org/10.3390/nu11102368 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sajoux, Ignacio
Lorenzo, Paula M.
Gomez-Arbelaez, Diego
Zulet, M. Angeles
Abete, Itziar
Castro, Ana I.
Baltar, Javier
Portillo, María P.
Tinahones, Francisco J.
Martinez, J. Alfredo
Crujeiras, Ana B.
Casanueva, Felipe F.
Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
title Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
title_full Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
title_fullStr Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
title_full_unstemmed Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
title_short Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity
title_sort effect of a very-low-calorie ketogenic diet on circulating myokine levels compared with the effect of bariatric surgery or a low-calorie diet in patients with obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835835/
https://www.ncbi.nlm.nih.gov/pubmed/31590286
http://dx.doi.org/10.3390/nu11102368
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