Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors
Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are elevated, regardless of the presence of obvious infection. It has been suggested to lead to chronic inflammation-related diseases such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFL...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835897/ https://www.ncbi.nlm.nih.gov/pubmed/31547555 http://dx.doi.org/10.3390/nu11102277 |
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author | Fuke, Nobuo Nagata, Naoto Suganuma, Hiroyuki Ota, Tsuguhito |
author_facet | Fuke, Nobuo Nagata, Naoto Suganuma, Hiroyuki Ota, Tsuguhito |
author_sort | Fuke, Nobuo |
collection | PubMed |
description | Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are elevated, regardless of the presence of obvious infection. It has been suggested to lead to chronic inflammation-related diseases such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), pancreatitis, amyotrophic lateral sclerosis, and Alzheimer’s disease. In addition, it has attracted attention as a target for the prevention and treatment of these chronic diseases. As metabolic endotoxemia was first reported in mice that were fed a high-fat diet, research regarding its relationship with diets has been actively conducted in humans and animals. In this review, we summarize the relationship between fat intake and induction of metabolic endotoxemia, focusing on gut dysbiosis and the influx, kinetics, and metabolism of LPS. We also summarize the recent findings about dietary factors that attenuate metabolic endotoxemia, focusing on the regulation of gut microbiota. We hope that in the future, control of metabolic endotoxemia using dietary factors will help maintain human health. |
format | Online Article Text |
id | pubmed-6835897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68358972019-11-25 Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors Fuke, Nobuo Nagata, Naoto Suganuma, Hiroyuki Ota, Tsuguhito Nutrients Review Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are elevated, regardless of the presence of obvious infection. It has been suggested to lead to chronic inflammation-related diseases such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), pancreatitis, amyotrophic lateral sclerosis, and Alzheimer’s disease. In addition, it has attracted attention as a target for the prevention and treatment of these chronic diseases. As metabolic endotoxemia was first reported in mice that were fed a high-fat diet, research regarding its relationship with diets has been actively conducted in humans and animals. In this review, we summarize the relationship between fat intake and induction of metabolic endotoxemia, focusing on gut dysbiosis and the influx, kinetics, and metabolism of LPS. We also summarize the recent findings about dietary factors that attenuate metabolic endotoxemia, focusing on the regulation of gut microbiota. We hope that in the future, control of metabolic endotoxemia using dietary factors will help maintain human health. MDPI 2019-09-23 /pmc/articles/PMC6835897/ /pubmed/31547555 http://dx.doi.org/10.3390/nu11102277 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fuke, Nobuo Nagata, Naoto Suganuma, Hiroyuki Ota, Tsuguhito Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors |
title | Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors |
title_full | Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors |
title_fullStr | Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors |
title_full_unstemmed | Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors |
title_short | Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors |
title_sort | regulation of gut microbiota and metabolic endotoxemia with dietary factors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835897/ https://www.ncbi.nlm.nih.gov/pubmed/31547555 http://dx.doi.org/10.3390/nu11102277 |
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