Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors

Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are elevated, regardless of the presence of obvious infection. It has been suggested to lead to chronic inflammation-related diseases such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFL...

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Autores principales: Fuke, Nobuo, Nagata, Naoto, Suganuma, Hiroyuki, Ota, Tsuguhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835897/
https://www.ncbi.nlm.nih.gov/pubmed/31547555
http://dx.doi.org/10.3390/nu11102277
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author Fuke, Nobuo
Nagata, Naoto
Suganuma, Hiroyuki
Ota, Tsuguhito
author_facet Fuke, Nobuo
Nagata, Naoto
Suganuma, Hiroyuki
Ota, Tsuguhito
author_sort Fuke, Nobuo
collection PubMed
description Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are elevated, regardless of the presence of obvious infection. It has been suggested to lead to chronic inflammation-related diseases such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), pancreatitis, amyotrophic lateral sclerosis, and Alzheimer’s disease. In addition, it has attracted attention as a target for the prevention and treatment of these chronic diseases. As metabolic endotoxemia was first reported in mice that were fed a high-fat diet, research regarding its relationship with diets has been actively conducted in humans and animals. In this review, we summarize the relationship between fat intake and induction of metabolic endotoxemia, focusing on gut dysbiosis and the influx, kinetics, and metabolism of LPS. We also summarize the recent findings about dietary factors that attenuate metabolic endotoxemia, focusing on the regulation of gut microbiota. We hope that in the future, control of metabolic endotoxemia using dietary factors will help maintain human health.
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spelling pubmed-68358972019-11-25 Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors Fuke, Nobuo Nagata, Naoto Suganuma, Hiroyuki Ota, Tsuguhito Nutrients Review Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are elevated, regardless of the presence of obvious infection. It has been suggested to lead to chronic inflammation-related diseases such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), pancreatitis, amyotrophic lateral sclerosis, and Alzheimer’s disease. In addition, it has attracted attention as a target for the prevention and treatment of these chronic diseases. As metabolic endotoxemia was first reported in mice that were fed a high-fat diet, research regarding its relationship with diets has been actively conducted in humans and animals. In this review, we summarize the relationship between fat intake and induction of metabolic endotoxemia, focusing on gut dysbiosis and the influx, kinetics, and metabolism of LPS. We also summarize the recent findings about dietary factors that attenuate metabolic endotoxemia, focusing on the regulation of gut microbiota. We hope that in the future, control of metabolic endotoxemia using dietary factors will help maintain human health. MDPI 2019-09-23 /pmc/articles/PMC6835897/ /pubmed/31547555 http://dx.doi.org/10.3390/nu11102277 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fuke, Nobuo
Nagata, Naoto
Suganuma, Hiroyuki
Ota, Tsuguhito
Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors
title Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors
title_full Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors
title_fullStr Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors
title_full_unstemmed Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors
title_short Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors
title_sort regulation of gut microbiota and metabolic endotoxemia with dietary factors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835897/
https://www.ncbi.nlm.nih.gov/pubmed/31547555
http://dx.doi.org/10.3390/nu11102277
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