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Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma

Melanoma is an aggressive form of skin cancer, being one of the deadliest cancers in the world. The current treatment options involve surgery, radiotherapy, targeted therapy, immunotherapy and the use of chemotherapeutic agents. Although the last approach is the most used, the high toxicity and the...

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Detalles Bibliográficos
Autores principales: Oliveira Pinho, Jacinta, Matias, Mariana, Gaspar, Maria Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836019/
https://www.ncbi.nlm.nih.gov/pubmed/31614947
http://dx.doi.org/10.3390/nano9101455
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author Oliveira Pinho, Jacinta
Matias, Mariana
Gaspar, Maria Manuela
author_facet Oliveira Pinho, Jacinta
Matias, Mariana
Gaspar, Maria Manuela
author_sort Oliveira Pinho, Jacinta
collection PubMed
description Melanoma is an aggressive form of skin cancer, being one of the deadliest cancers in the world. The current treatment options involve surgery, radiotherapy, targeted therapy, immunotherapy and the use of chemotherapeutic agents. Although the last approach is the most used, the high toxicity and the lack of efficacy in advanced stages of the disease have demanded the search for novel bioactive molecules and/or efficient drug delivery systems. The current review aims to discuss the most recent advances on the elucidation of potential targets for melanoma treatment, such as aquaporin-3 and tyrosinase. In addition, the role of nanotechnology as a valuable strategy to effectively deliver selective drugs is emphasized, either incorporating/encapsulating synthetic molecules or natural-derived compounds in lipid-based nanosystems such as liposomes. Nanoformulated compounds have been explored for their improved anticancer activity against melanoma and promising results have been obtained. Indeed, they displayed improved physicochemical properties and higher accumulation in tumoral tissues, which potentiated the efficacy of the compounds in pre-clinical experiments. Overall, these experiments opened new doors for the discovery and development of more effective drug formulations for melanoma treatment.
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spelling pubmed-68360192019-11-25 Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma Oliveira Pinho, Jacinta Matias, Mariana Gaspar, Maria Manuela Nanomaterials (Basel) Review Melanoma is an aggressive form of skin cancer, being one of the deadliest cancers in the world. The current treatment options involve surgery, radiotherapy, targeted therapy, immunotherapy and the use of chemotherapeutic agents. Although the last approach is the most used, the high toxicity and the lack of efficacy in advanced stages of the disease have demanded the search for novel bioactive molecules and/or efficient drug delivery systems. The current review aims to discuss the most recent advances on the elucidation of potential targets for melanoma treatment, such as aquaporin-3 and tyrosinase. In addition, the role of nanotechnology as a valuable strategy to effectively deliver selective drugs is emphasized, either incorporating/encapsulating synthetic molecules or natural-derived compounds in lipid-based nanosystems such as liposomes. Nanoformulated compounds have been explored for their improved anticancer activity against melanoma and promising results have been obtained. Indeed, they displayed improved physicochemical properties and higher accumulation in tumoral tissues, which potentiated the efficacy of the compounds in pre-clinical experiments. Overall, these experiments opened new doors for the discovery and development of more effective drug formulations for melanoma treatment. MDPI 2019-10-13 /pmc/articles/PMC6836019/ /pubmed/31614947 http://dx.doi.org/10.3390/nano9101455 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oliveira Pinho, Jacinta
Matias, Mariana
Gaspar, Maria Manuela
Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma
title Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma
title_full Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma
title_fullStr Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma
title_full_unstemmed Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma
title_short Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma
title_sort emergent nanotechnological strategies for systemic chemotherapy against melanoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836019/
https://www.ncbi.nlm.nih.gov/pubmed/31614947
http://dx.doi.org/10.3390/nano9101455
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