Cargando…

Mediating-Moderating Effect of Allostatic Load on the Association between Dietary Approaches to Stop Hypertension Diet and All-Cause and Cause-Specific Mortality: 2001–2010 National Health and Nutrition Examination Surveys

This secondary analysis of survey data examined mediating-moderating effects of allostatic load score (calculated using the Rodriquez method) on the association between nutrient-based Dietary Approaches to Stop Hypertension (DASH) diet score (Mellen Index) and the all-cause and cause-specific mortal...

Descripción completa

Detalles Bibliográficos
Autores principales: Beydoun, Hind A., Huang, Shuyan, Beydoun, May A., Hossain, Sharmin, Zonderman, Alan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836046/
https://www.ncbi.nlm.nih.gov/pubmed/31569527
http://dx.doi.org/10.3390/nu11102311
_version_ 1783466816657424384
author Beydoun, Hind A.
Huang, Shuyan
Beydoun, May A.
Hossain, Sharmin
Zonderman, Alan B.
author_facet Beydoun, Hind A.
Huang, Shuyan
Beydoun, May A.
Hossain, Sharmin
Zonderman, Alan B.
author_sort Beydoun, Hind A.
collection PubMed
description This secondary analysis of survey data examined mediating-moderating effects of allostatic load score (calculated using the Rodriquez method) on the association between nutrient-based Dietary Approaches to Stop Hypertension (DASH) diet score (Mellen Index) and the all-cause and cause-specific mortality risks among 11,630 adults ≥ 30 years of age from the 2001–2010 National Health and Nutrition Examination Surveys with no history of cardiovascular disease or cancer at baseline, and who were followed-up for ~9.35 years. Multivariable models were adjusted for demographic, socioeconomic, lifestyle, and health characteristics. All-cause, cardiovascular disease, and cancer-specific mortality rates were estimated at 6.5%, 1.1%, and 1.9%, respectively. The median DASH total score was 3.0 (range: 1–8) (with 78.3% scoring < 4.5), whereas the median allostatic load score was 3 (range: 0–9). The DASH diet, fiber, and magnesium were negatively correlated with allostatic load, whereas allostatic load predicted higher all-cause mortality, irrespective of the DASH diet. Whereas protein was protective, potassium increased all-cause mortality risk, irrespective of allostatic load. Potassium was protective against cardiovascular disease-specific mortality but was a risk factor for cancer-specific mortality. Although no moderating effects were observed, mediation by the allostatic load on cardiovascular disease-specific mortality was observed for DASH total score and selected component scores. Direct (but not indirect) effects of DASH through the allostatic load were observed for all-cause mortality, and no direct or indirect effects were observed for cancer-specific mortality. From a public health standpoint, the allostatic load may be a surrogate for the preventive effects of the DASH diet and its components on cardiovascular disease-specific mortality risk.
format Online
Article
Text
id pubmed-6836046
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-68360462019-11-25 Mediating-Moderating Effect of Allostatic Load on the Association between Dietary Approaches to Stop Hypertension Diet and All-Cause and Cause-Specific Mortality: 2001–2010 National Health and Nutrition Examination Surveys Beydoun, Hind A. Huang, Shuyan Beydoun, May A. Hossain, Sharmin Zonderman, Alan B. Nutrients Article This secondary analysis of survey data examined mediating-moderating effects of allostatic load score (calculated using the Rodriquez method) on the association between nutrient-based Dietary Approaches to Stop Hypertension (DASH) diet score (Mellen Index) and the all-cause and cause-specific mortality risks among 11,630 adults ≥ 30 years of age from the 2001–2010 National Health and Nutrition Examination Surveys with no history of cardiovascular disease or cancer at baseline, and who were followed-up for ~9.35 years. Multivariable models were adjusted for demographic, socioeconomic, lifestyle, and health characteristics. All-cause, cardiovascular disease, and cancer-specific mortality rates were estimated at 6.5%, 1.1%, and 1.9%, respectively. The median DASH total score was 3.0 (range: 1–8) (with 78.3% scoring < 4.5), whereas the median allostatic load score was 3 (range: 0–9). The DASH diet, fiber, and magnesium were negatively correlated with allostatic load, whereas allostatic load predicted higher all-cause mortality, irrespective of the DASH diet. Whereas protein was protective, potassium increased all-cause mortality risk, irrespective of allostatic load. Potassium was protective against cardiovascular disease-specific mortality but was a risk factor for cancer-specific mortality. Although no moderating effects were observed, mediation by the allostatic load on cardiovascular disease-specific mortality was observed for DASH total score and selected component scores. Direct (but not indirect) effects of DASH through the allostatic load were observed for all-cause mortality, and no direct or indirect effects were observed for cancer-specific mortality. From a public health standpoint, the allostatic load may be a surrogate for the preventive effects of the DASH diet and its components on cardiovascular disease-specific mortality risk. MDPI 2019-09-29 /pmc/articles/PMC6836046/ /pubmed/31569527 http://dx.doi.org/10.3390/nu11102311 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Beydoun, Hind A.
Huang, Shuyan
Beydoun, May A.
Hossain, Sharmin
Zonderman, Alan B.
Mediating-Moderating Effect of Allostatic Load on the Association between Dietary Approaches to Stop Hypertension Diet and All-Cause and Cause-Specific Mortality: 2001–2010 National Health and Nutrition Examination Surveys
title Mediating-Moderating Effect of Allostatic Load on the Association between Dietary Approaches to Stop Hypertension Diet and All-Cause and Cause-Specific Mortality: 2001–2010 National Health and Nutrition Examination Surveys
title_full Mediating-Moderating Effect of Allostatic Load on the Association between Dietary Approaches to Stop Hypertension Diet and All-Cause and Cause-Specific Mortality: 2001–2010 National Health and Nutrition Examination Surveys
title_fullStr Mediating-Moderating Effect of Allostatic Load on the Association between Dietary Approaches to Stop Hypertension Diet and All-Cause and Cause-Specific Mortality: 2001–2010 National Health and Nutrition Examination Surveys
title_full_unstemmed Mediating-Moderating Effect of Allostatic Load on the Association between Dietary Approaches to Stop Hypertension Diet and All-Cause and Cause-Specific Mortality: 2001–2010 National Health and Nutrition Examination Surveys
title_short Mediating-Moderating Effect of Allostatic Load on the Association between Dietary Approaches to Stop Hypertension Diet and All-Cause and Cause-Specific Mortality: 2001–2010 National Health and Nutrition Examination Surveys
title_sort mediating-moderating effect of allostatic load on the association between dietary approaches to stop hypertension diet and all-cause and cause-specific mortality: 2001–2010 national health and nutrition examination surveys
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836046/
https://www.ncbi.nlm.nih.gov/pubmed/31569527
http://dx.doi.org/10.3390/nu11102311
work_keys_str_mv AT beydounhinda mediatingmoderatingeffectofallostaticloadontheassociationbetweendietaryapproachestostophypertensiondietandallcauseandcausespecificmortality20012010nationalhealthandnutritionexaminationsurveys
AT huangshuyan mediatingmoderatingeffectofallostaticloadontheassociationbetweendietaryapproachestostophypertensiondietandallcauseandcausespecificmortality20012010nationalhealthandnutritionexaminationsurveys
AT beydounmaya mediatingmoderatingeffectofallostaticloadontheassociationbetweendietaryapproachestostophypertensiondietandallcauseandcausespecificmortality20012010nationalhealthandnutritionexaminationsurveys
AT hossainsharmin mediatingmoderatingeffectofallostaticloadontheassociationbetweendietaryapproachestostophypertensiondietandallcauseandcausespecificmortality20012010nationalhealthandnutritionexaminationsurveys
AT zondermanalanb mediatingmoderatingeffectofallostaticloadontheassociationbetweendietaryapproachestostophypertensiondietandallcauseandcausespecificmortality20012010nationalhealthandnutritionexaminationsurveys