Culture-negative periprosthetic joint infections

Culture-negative periprosthetic joint infections (CN-PJI) pose a significant challenge in terms of diagnosis and management. The reported incidence of CN-PJI is reported to be between 7% and 15%. Fungi and mycobacterium are thought to be responsible for over 85% of such cases with more fastidious ba...

Descripción completa

Detalles Bibliográficos
Autores principales: Palan, Jeya, Nolan, Ciaran, Sarantos, Kostas, Westerman, Richard, King, Richard, Foguet, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: British Editorial Society of Bone and Joint Surgery 2019
Materias:
General Orthopaedics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836077/
https://www.ncbi.nlm.nih.gov/pubmed/31754464
http://dx.doi.org/10.1302/2058-5241.4.180067
_version_ 1783466824102313984
author Palan, Jeya
Nolan, Ciaran
Sarantos, Kostas
Westerman, Richard
King, Richard
Foguet, Pedro
author_facet Palan, Jeya
Nolan, Ciaran
Sarantos, Kostas
Westerman, Richard
King, Richard
Foguet, Pedro
author_sort Palan, Jeya
collection PubMed
description Culture-negative periprosthetic joint infections (CN-PJI) pose a significant challenge in terms of diagnosis and management. The reported incidence of CN-PJI is reported to be between 7% and 15%. Fungi and mycobacterium are thought to be responsible for over 85% of such cases with more fastidious bacteria accounting for the rest. With the advent of polymerase chain reaction, mass spectrometry and next generation sequencing, identifying the causative organism(s) may become easier but such techniques are not readily available and are very costly. There are a number of more straightforward and relatively low-cost methods to help surgeons maximize the chances of diagnosing a PJI and identify the organisms responsible. This review article summarizes the main diagnostic tests currently available as well as providing a simple diagnostic clinical algorithm for CN-PJI. Cite this article: EFORT Open Rev 2019;4:585-594. DOI: 10.1302/2058-5241.4.180067
format Online
Article
Text
id pubmed-6836077
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher British Editorial Society of Bone and Joint Surgery
record_format MEDLINE/PubMed
spelling pubmed-68360772019-11-21 Culture-negative periprosthetic joint infections Palan, Jeya Nolan, Ciaran Sarantos, Kostas Westerman, Richard King, Richard Foguet, Pedro EFORT Open Rev General Orthopaedics Culture-negative periprosthetic joint infections (CN-PJI) pose a significant challenge in terms of diagnosis and management. The reported incidence of CN-PJI is reported to be between 7% and 15%. Fungi and mycobacterium are thought to be responsible for over 85% of such cases with more fastidious bacteria accounting for the rest. With the advent of polymerase chain reaction, mass spectrometry and next generation sequencing, identifying the causative organism(s) may become easier but such techniques are not readily available and are very costly. There are a number of more straightforward and relatively low-cost methods to help surgeons maximize the chances of diagnosing a PJI and identify the organisms responsible. This review article summarizes the main diagnostic tests currently available as well as providing a simple diagnostic clinical algorithm for CN-PJI. Cite this article: EFORT Open Rev 2019;4:585-594. DOI: 10.1302/2058-5241.4.180067 British Editorial Society of Bone and Joint Surgery 2019-10-07 /pmc/articles/PMC6836077/ /pubmed/31754464 http://dx.doi.org/10.1302/2058-5241.4.180067 Text en © 2019 The author(s) https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed.
spellingShingle General Orthopaedics
Palan, Jeya
Nolan, Ciaran
Sarantos, Kostas
Westerman, Richard
King, Richard
Foguet, Pedro
Culture-negative periprosthetic joint infections
title Culture-negative periprosthetic joint infections
title_full Culture-negative periprosthetic joint infections
title_fullStr Culture-negative periprosthetic joint infections
title_full_unstemmed Culture-negative periprosthetic joint infections
title_short Culture-negative periprosthetic joint infections
title_sort culture-negative periprosthetic joint infections
topic General Orthopaedics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836077/
https://www.ncbi.nlm.nih.gov/pubmed/31754464
http://dx.doi.org/10.1302/2058-5241.4.180067
work_keys_str_mv AT palanjeya culturenegativeperiprostheticjointinfections
AT nolanciaran culturenegativeperiprostheticjointinfections
AT sarantoskostas culturenegativeperiprostheticjointinfections
AT westermanrichard culturenegativeperiprostheticjointinfections
AT kingrichard culturenegativeperiprostheticjointinfections
AT foguetpedro culturenegativeperiprostheticjointinfections

Ejemplares similares