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IFN-γ down-regulates the PD-1 expression and assist nivolumab in PD-1-blockade effect on CD8+ T-lymphocytes in pancreatic cancer

BACKGROUND: Pancreatic cancer is characterized by a highly immunosuppressive tumor microenvironment and evasion of immune surveillance. Although programmed cell death 1 receptor (PD-1) blockade has achieved certain success in immunogenic cancers, the responses to the PD-1 antibody are not effective...

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Detalles Bibliográficos
Autores principales:	Ding, Guoping, Shen, Tao, Yan, Chen, Zhang, Mingjie, Wu, Zhengrong, Cao, Liping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836337/ https://www.ncbi.nlm.nih.gov/pubmed/31694582 http://dx.doi.org/10.1186/s12885-019-6145-8

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