Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS

A decade has passed since the publication on the comparison of the effect of adalimumab with data from a historic cohort on the progression of structural damage in the spine of patients with ankylosing spondylitis (AS). No effect could be observed, and currently, there is still no definite proof tha...

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Detalles Bibliográficos
Autores principales: van der Heijde, Désirée, Landewé, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836371/
https://www.ncbi.nlm.nih.gov/pubmed/31694713
http://dx.doi.org/10.1186/s13075-019-2045-1
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author van der Heijde, Désirée
Landewé, Robert
author_facet van der Heijde, Désirée
Landewé, Robert
author_sort van der Heijde, Désirée
collection PubMed
description A decade has passed since the publication on the comparison of the effect of adalimumab with data from a historic cohort on the progression of structural damage in the spine of patients with ankylosing spondylitis (AS). No effect could be observed, and currently, there is still no definite proof that TNF inhibitors (TNFi) inhibit spinal structural damage. The findings of the publication are discussed within the context of the time at the publication and new developments.
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spelling pubmed-68363712019-11-08 Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS van der Heijde, Désirée Landewé, Robert Arthritis Res Ther Editorial A decade has passed since the publication on the comparison of the effect of adalimumab with data from a historic cohort on the progression of structural damage in the spine of patients with ankylosing spondylitis (AS). No effect could be observed, and currently, there is still no definite proof that TNF inhibitors (TNFi) inhibit spinal structural damage. The findings of the publication are discussed within the context of the time at the publication and new developments. BioMed Central 2019-11-06 2019 /pmc/articles/PMC6836371/ /pubmed/31694713 http://dx.doi.org/10.1186/s13075-019-2045-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Editorial
van der Heijde, Désirée
Landewé, Robert
Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS
title Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS
title_full Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS
title_fullStr Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS
title_full_unstemmed Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS
title_short Inhibition of spinal bone formation in AS: 10 years after comparing adalimumab to OASIS
title_sort inhibition of spinal bone formation in as: 10 years after comparing adalimumab to oasis
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836371/
https://www.ncbi.nlm.nih.gov/pubmed/31694713
http://dx.doi.org/10.1186/s13075-019-2045-1
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