Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a

BACKGROUND: NGF-TrkA is well known to play a key role in propagating and sustaining pruritogenic signals, which form the pathology of chronic pruritus. Inhibition of NGF-TrkA is a known strategy for the treatment of pruritus. In the present paper, we describe the identification, in vitro characteriz...

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Detalles Bibliográficos
Autores principales: Zhong, Yueling, Xu, Hong, Zhong, Yi, Zhang, Xuemiao, Zeng, Ting, Li, Limei, Xu, Gaojie, Li, Minhui, Liu, Jin, Yang, Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836411/
https://www.ncbi.nlm.nih.gov/pubmed/31694615
http://dx.doi.org/10.1186/s12906-019-2709-z

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