ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis

BACKGROUND: Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell co...

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Detalles Bibliográficos
Autores principales: Lin, Qiushi, Chen, Xuesong, Meng, Fanzheng, Ogawa, Kosuke, Li, Min, Song, Ruipeng, Zhang, Shugeng, Zhang, Ziran, Kong, Xianglu, Xu, Qinggang, He, Fuliang, Bai, Xuewei, Sun, Bei, Hung, Mien-Chie, Liu, Lianxin, Wands, Jack, Dong, Xiaoqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836474/
https://www.ncbi.nlm.nih.gov/pubmed/31694640
http://dx.doi.org/10.1186/s12943-019-1077-0

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