Cargando…

NOTCH2 negatively regulates metastasis and epithelial-Mesenchymal transition via TRAF6/AKT in nasopharyngeal carcinoma

BACKGROUND: Clinically, distant metastasis after primary treatment remains a key problem in nasopharyngeal carcinoma (NPC). Thus, identification of the underlying mechanisms and development of novel therapeutic strategies are urgently needed. NOTCH has been shown to function as a tumor promotor that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zou, You, Yang, Rui, Huang, Mao-Ling, Kong, Yong-Gang, Sheng, Jian-Fei, Tao, Ze-Zhang, Gao, Ling, Chen, Shi-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836530/ https://www.ncbi.nlm.nih.gov/pubmed/31699119 http://dx.doi.org/10.1186/s13046-019-1463-x

Ejemplares similares

Overexpression of Notch2 enhances radiosensitivity via inhibition of the AKT/mTOR signaling pathway in nasopharyngeal carcinoma
por: Wu, Li-Zhi, et al.
Publicado: (2021)

Oridonin inhibits epithelial-mesenchymal transition of human nasopharyngeal carcinoma cells by negatively regulating AKT/STAT3 signaling pathway
por: Liu, Wei, et al.
Publicado: (2021)

Goosecoid Promotes the Metastasis of Hepatocellular Carcinoma by Modulating the Epithelial-Mesenchymal Transition
por: Xue, Tong-Chun, et al.
Publicado: (2014)

TRAF4 Regulates Migration, Invasion, and Epithelial–Mesenchymal Transition via PI3K/AKT Signaling in Hepatocellular Carcinoma
por: Liu, Kairui, et al.
Publicado: (2017)

Effect of AKT inhibition on epithelial-mesenchymal transition and ZEB1-potentiated radiotherapy in nasopharyngeal carcinoma
por: CHEN, WEIGUO, et al.
Publicado: (2013)

NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling
por: Zhang, Jianchao, et al.
Publicado: (2016)

Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer
por: Pal, Deeksha, et al.
Publicado: (2018)

Epithelial cell adhesion molecule overexpression regulates epithelial-mesenchymal transition, stemness and metastasis of nasopharyngeal carcinoma cells via the PTEN/AKT/mTOR pathway
por: Wang, Meng-He, et al.
Publicado: (2018)

Plac8‐mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT/mTOR pathway
por: Huang, Mao‐Ling, et al.
Publicado: (2020)

As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial–mesenchymal transition and activation of AKT signaling
por: Li, Xin-Jian, et al.
Publicado: (2012)

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut
por: Chanrion, Maia, et al.
Publicado: (2014)

Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity
por: Noh, Hae Sook, et al.
Publicado: (2015)

Tspan5 promotes epithelial–mesenchymal transition and tumour metastasis of hepatocellular carcinoma by activating Notch signalling
por: Xie, Qian, et al.
Publicado: (2021)

Autophagy-mediated degradation of NOTCH1 intracellular domain controls the epithelial to mesenchymal transition and cancer metastasis
por: Zada, Sahib, et al.
Publicado: (2022)

Effect of Shengmai Yin on Epithelial-Mesenchymal Transition of Nasopharyngeal Carcinoma Radioresistant Cells
por: Wang, Ze-tai, et al.
Publicado: (2022)

OVOL2 links stemness and metastasis via fine-tuning epithelial-mesenchymal transition in nasopharyngeal carcinoma
por: Qi, Xue-Kang, et al.
Publicado: (2018)

Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial–mesenchymal transition and metastasis
por: Zhang, Ting, et al.
Publicado: (2017)

LGR5 promotes epithelial ovarian cancer proliferation, metastasis, and epithelial–mesenchymal transition through the Notch1 signaling pathway
por: Liu, Wenxue, et al.
Publicado: (2018)

Epithelial–mesenchymal transition in tumor metastasis
por: Yeung, Kay T., et al.
Publicado: (2016)

Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway
por: Wang, Sheng-Chun, et al.
Publicado: (2015)

Suppression of the epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1 signaling pathway in metastasis of endometrial cancer
por: Liao, Yun, et al.
Publicado: (2014)

c-Src activation promotes nasopharyngeal carcinoma metastasis by inducing the epithelial-mesenchymal transition via PI3K/Akt signaling pathway: a new and promising target for NPC
por: Ke, Liangru, et al.
Publicado: (2016)

Maelstrom promotes tumor metastasis through regulation of FGFR4 and epithelial-mesenchymal transition in epithelial ovarian cancer
por: He, Wei-Peng, et al.
Publicado: (2022)

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
por: Espinoza, Ingrid, et al.
Publicado: (2013)

Correction: Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial–mesenchymal transition and metastasis
por: Zhang, Ting, et al.
Publicado: (2018)

NFAT1 Hypermethylation Promotes Epithelial-Mesenchymal Transition and Metastasis in Nasopharyngeal Carcinoma by Activating ITGA6 Transcription()()
por: Zhang, Jian, et al.
Publicado: (2019)

Epithelial-Mesenchymal Transition during Metastasis of HPV-Negative Pharyngeal Squamous Cell Carcinoma
por: Ihler, Friedrich, et al.
Publicado: (2018)

Effects of HOX transcript antisense intergenic RNA on the metastasis, epithelial-mesenchymal transition, and Notch signaling pathway in tongue cancer
por: Zhang, Yang, et al.
Publicado: (2021)

Notch signaling is important for epithelial-mesenchymal transition induced by low concentrations of doxorubicin in osteosarcoma cell lines
por: Yang, Jian, et al.
Publicado: (2017)

MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer
por: Li, Jiazhi, et al.
Publicado: (2018)

HMGA2 is associated with epithelial–mesenchymal transition and can predict poor prognosis in nasopharyngeal carcinoma
por: Xia, You-You, et al.
Publicado: (2015)

LINC01268 promotes epithelial-mesenchymal transition, invasion and metastasis of gastric cancer via the PI3K/Akt signaling pathway and targeting MARCKS
por: Tang, Ling-Han, et al.
Publicado: (2023)

3,3′-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition
por: WU, TINGTING, et al.
Publicado: (2014)

Flotillin-2 promotes nasopharyngeal carcinoma metastasis and is necessary for the epithelial-mesenchymal transition induced by transforming growth factor-β
por: Zhao, Liang, et al.
Publicado: (2015)

hsa-miR-24 suppresses metastasis in nasopharyngeal carcinoma by regulating the c-Myc/epithelial-mesenchymal transition axis
por: Su, Bojin, et al.
Publicado: (2018)

miR-137 Inhibition of the Invasion, Metastasis, and Epithelial-Mesenchymal Transition of Nasopharyngeal Cancer by Regulating KDM1A
por: Lu, Han-qiang, et al.
Publicado: (2021)

Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer
por: Kim, Rae-Kwon, et al.
Publicado: (2016)

Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling
por: Bocci, Federico, et al.
Publicado: (2017)

A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer
por: Kar, Rohan, et al.
Publicado: (2019)

Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT)
por: Li, Jianlong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4pac4694sngksvtdefrm8eb2lb