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DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits
The driver tissues or cell types in which susceptibility genes initiate diseases remain elusive. We develop a unified framework to detect the causal tissues of complex diseases or traits according to selective expression of disease-associated genes in genome-wide association studies (GWASs). This fr...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836538/ https://www.ncbi.nlm.nih.gov/pubmed/31694669 http://dx.doi.org/10.1186/s13059-019-1801-5 |