Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network

BACKGROUND: MYO1C, an actin-based motor protein, is involved in the late stages of autophagosome maturation and fusion with the lysosome. The molecular mechanism by which MYO1C regulates autophagosome-lysosome fusion remains largely unclear. METHODS: Western blotting was used to determine the expres...

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Detalles Bibliográficos
Autores principales: Zhang, Yanhao, Jiang, Xiuxing, Deng, Qin, Gao, Ziyi, Tang, Xiangyu, Fu, Ruoqiu, Hu, Jinjiao, Li, Yunong, Li, Lirong, Gao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836678/
https://www.ncbi.nlm.nih.gov/pubmed/31699152
http://dx.doi.org/10.1186/s13046-019-1449-8

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