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Investigation of GTP-dependent dimerization of G12X K-Ras variants using ultraviolet photodissociation mass spectrometry

Mutations in the GTPase enzyme K-Ras, specifically at codon G12, remain the most common genetic alterations in human cancers. The mechanisms governing activation of downstream signaling pathways and how they relate back to the identity of the mutation have yet to be completely defined. Here we use n...

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Detalles Bibliográficos
Autores principales:	Mehaffey, M. Rachel, Schardon, Christopher L., Novelli, Elisa T., Cammarata, Michael B., Webb, Lauren J., Fast, Walter, Brodbelt, Jennifer S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837035/ https://www.ncbi.nlm.nih.gov/pubmed/31853358 http://dx.doi.org/10.1039/c9sc01032g

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