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Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations

Background: Evidence indicates that the serum concentration of uric acid (UA) in patients may relate both to the pathophysiology and therapeutics of bipolar disorder (BPD). The purpose of this study was to examine the changes and clinical significance of serum UA concentrations in first-episode mani...

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Autores principales: Chen, Jing-Xu, Zhang, Li-Gang, Liu, Ke-Zhi, Chen, Hong-Mei, Zhou, Shuang-Jiang, Wang, Ning, Tan, Yun-Long, Wang, Shao-Li, Jones, Alison, Yang, Fu-De, Huang, Xu-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837074/
https://www.ncbi.nlm.nih.gov/pubmed/31736796
http://dx.doi.org/10.3389/fpsyt.2019.00767
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author Chen, Jing-Xu
Zhang, Li-Gang
Liu, Ke-Zhi
Chen, Hong-Mei
Zhou, Shuang-Jiang
Wang, Ning
Tan, Yun-Long
Wang, Shao-Li
Jones, Alison
Yang, Fu-De
Huang, Xu-Feng
author_facet Chen, Jing-Xu
Zhang, Li-Gang
Liu, Ke-Zhi
Chen, Hong-Mei
Zhou, Shuang-Jiang
Wang, Ning
Tan, Yun-Long
Wang, Shao-Li
Jones, Alison
Yang, Fu-De
Huang, Xu-Feng
author_sort Chen, Jing-Xu
collection PubMed
description Background: Evidence indicates that the serum concentration of uric acid (UA) in patients may relate both to the pathophysiology and therapeutics of bipolar disorder (BPD). The purpose of this study was to examine the changes and clinical significance of serum UA concentrations in first-episode manic patients suffering from BPD. Methods: Seventy-six drug-naive patients with first-episode bipolar mania and 76 age- and gender-matched healthy subjects were recruited. Young Mania Rating Scale and Hamilton Depression Rating Scale were used to assess clinical symptoms. We tested serum UA concentrations by sandwich enzyme-linked immunosorbent assay at baseline and at the end of 8-week treatment in BPD patients and in the control group. Results: After 8-week quetiapine and sodium valproate treatment, this study revealed that the serum UA concentrations in remitted patients were significantly lower than nonremitted patients; however, those remitted patients still had higher serum UA than healthy controls. We discovered that the baseline UA concentration was higher in nonremitted than remitted patients after 8 weeks of treatment. Finally, a positive association was found between serum UA and symptom relief in the first episode of manic disorder patients. Conclusion: Patients with first-episode BPD had high levels of serum UA, which responds to treatment mainly in remitted patients. Our results suggest that serum UA concentrations might present potentially a trait marker in bipolar patients.
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spelling pubmed-68370742019-11-15 Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations Chen, Jing-Xu Zhang, Li-Gang Liu, Ke-Zhi Chen, Hong-Mei Zhou, Shuang-Jiang Wang, Ning Tan, Yun-Long Wang, Shao-Li Jones, Alison Yang, Fu-De Huang, Xu-Feng Front Psychiatry Psychiatry Background: Evidence indicates that the serum concentration of uric acid (UA) in patients may relate both to the pathophysiology and therapeutics of bipolar disorder (BPD). The purpose of this study was to examine the changes and clinical significance of serum UA concentrations in first-episode manic patients suffering from BPD. Methods: Seventy-six drug-naive patients with first-episode bipolar mania and 76 age- and gender-matched healthy subjects were recruited. Young Mania Rating Scale and Hamilton Depression Rating Scale were used to assess clinical symptoms. We tested serum UA concentrations by sandwich enzyme-linked immunosorbent assay at baseline and at the end of 8-week treatment in BPD patients and in the control group. Results: After 8-week quetiapine and sodium valproate treatment, this study revealed that the serum UA concentrations in remitted patients were significantly lower than nonremitted patients; however, those remitted patients still had higher serum UA than healthy controls. We discovered that the baseline UA concentration was higher in nonremitted than remitted patients after 8 weeks of treatment. Finally, a positive association was found between serum UA and symptom relief in the first episode of manic disorder patients. Conclusion: Patients with first-episode BPD had high levels of serum UA, which responds to treatment mainly in remitted patients. Our results suggest that serum UA concentrations might present potentially a trait marker in bipolar patients. Frontiers Media S.A. 2019-10-31 /pmc/articles/PMC6837074/ /pubmed/31736796 http://dx.doi.org/10.3389/fpsyt.2019.00767 Text en Copyright © 2019 Chen, Zhang, Liu, Chen, Zhou, Wang, Tan, Wang, Jones, Yang and Huang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Chen, Jing-Xu
Zhang, Li-Gang
Liu, Ke-Zhi
Chen, Hong-Mei
Zhou, Shuang-Jiang
Wang, Ning
Tan, Yun-Long
Wang, Shao-Li
Jones, Alison
Yang, Fu-De
Huang, Xu-Feng
Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations
title Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations
title_full Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations
title_fullStr Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations
title_full_unstemmed Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations
title_short Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations
title_sort patients with drug-naive bipolar disorder in remission after 8 weeks of treatment had decreased serum uric acid concentrations
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837074/
https://www.ncbi.nlm.nih.gov/pubmed/31736796
http://dx.doi.org/10.3389/fpsyt.2019.00767
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