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Relationship between pattern electroretinogram and optic disc morphology in glaucoma

PURPOSE: To evaluate the relationship between pattern electroretinogram (PERG) and optic disc morphology in glaucoma suspect and glaucoma. METHODS: Eighty-six eyes of glaucoma suspect and 145 eyes of manifest glaucoma subjects were included in this study. Average peripapillary retinal nerve fiber la...

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Autores principales: Jeon, Soo Ji, Park, Hae-Young Lopilly, Jung, Kyoung In, Park, Chan Kee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837750/
https://www.ncbi.nlm.nih.gov/pubmed/31697709
http://dx.doi.org/10.1371/journal.pone.0220992
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author Jeon, Soo Ji
Park, Hae-Young Lopilly
Jung, Kyoung In
Park, Chan Kee
author_facet Jeon, Soo Ji
Park, Hae-Young Lopilly
Jung, Kyoung In
Park, Chan Kee
author_sort Jeon, Soo Ji
collection PubMed
description PURPOSE: To evaluate the relationship between pattern electroretinogram (PERG) and optic disc morphology in glaucoma suspect and glaucoma. METHODS: Eighty-six eyes of glaucoma suspect and 145 eyes of manifest glaucoma subjects were included in this study. Average peripapillary retinal nerve fiber layer (RNFL) thickness was obtained with spectral-domain optical coherence tomography, and optic disc imaging was performed using the Heidelberg Retinal Tomograph (HRT). Visual function was evaluated with perimetry (SITA and frequency doubling technology) and PERG. Scatter plots and correlation coefficients were evaluated between visual function and RNFL thickness or optic disc structure. RESULTS: Scatter plots of PERG and perimetry according to RNFL thickness change showed that PERG started to decrease earlier than did perimetry. The differences between linear and logarithmic R(2) were largest for the scatter plot of SITA 24–2 (linear R(2) = 0.415; logarithmic R(2) = 0.443) and the smallest for P50 amplitude of PERG (linear R(2) = 0.136, logarithmic R(2) = 0.138). In glaucoma suspect, HRT parameters such as cup shape measure (CSM) and linear cup-disc ratio (CDR) had significant correlations with PERG amplitudes (P = 0.016 for P50 and 0.049 for N95 in CSM, P = 0.012 for P50 in CDR). However, in glaucoma patients, mean RNFL thickness was associated with PERG amplitude (P = 0.011 for P50 and 0.002 for N95). CONCLUSIONS: PERG deterioration occurred earlier than did perimetry according to RNFL thickness decrease. PERG amplitudes were significantly correlated with disc morphology in glaucoma suspect. These results suggest that PERG can detect ganglion cell dysfunction before the cells die.
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spelling pubmed-68377502019-11-14 Relationship between pattern electroretinogram and optic disc morphology in glaucoma Jeon, Soo Ji Park, Hae-Young Lopilly Jung, Kyoung In Park, Chan Kee PLoS One Research Article PURPOSE: To evaluate the relationship between pattern electroretinogram (PERG) and optic disc morphology in glaucoma suspect and glaucoma. METHODS: Eighty-six eyes of glaucoma suspect and 145 eyes of manifest glaucoma subjects were included in this study. Average peripapillary retinal nerve fiber layer (RNFL) thickness was obtained with spectral-domain optical coherence tomography, and optic disc imaging was performed using the Heidelberg Retinal Tomograph (HRT). Visual function was evaluated with perimetry (SITA and frequency doubling technology) and PERG. Scatter plots and correlation coefficients were evaluated between visual function and RNFL thickness or optic disc structure. RESULTS: Scatter plots of PERG and perimetry according to RNFL thickness change showed that PERG started to decrease earlier than did perimetry. The differences between linear and logarithmic R(2) were largest for the scatter plot of SITA 24–2 (linear R(2) = 0.415; logarithmic R(2) = 0.443) and the smallest for P50 amplitude of PERG (linear R(2) = 0.136, logarithmic R(2) = 0.138). In glaucoma suspect, HRT parameters such as cup shape measure (CSM) and linear cup-disc ratio (CDR) had significant correlations with PERG amplitudes (P = 0.016 for P50 and 0.049 for N95 in CSM, P = 0.012 for P50 in CDR). However, in glaucoma patients, mean RNFL thickness was associated with PERG amplitude (P = 0.011 for P50 and 0.002 for N95). CONCLUSIONS: PERG deterioration occurred earlier than did perimetry according to RNFL thickness decrease. PERG amplitudes were significantly correlated with disc morphology in glaucoma suspect. These results suggest that PERG can detect ganglion cell dysfunction before the cells die. Public Library of Science 2019-11-07 /pmc/articles/PMC6837750/ /pubmed/31697709 http://dx.doi.org/10.1371/journal.pone.0220992 Text en © 2019 Jeon et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Jeon, Soo Ji
Park, Hae-Young Lopilly
Jung, Kyoung In
Park, Chan Kee
Relationship between pattern electroretinogram and optic disc morphology in glaucoma
title Relationship between pattern electroretinogram and optic disc morphology in glaucoma
title_full Relationship between pattern electroretinogram and optic disc morphology in glaucoma
title_fullStr Relationship between pattern electroretinogram and optic disc morphology in glaucoma
title_full_unstemmed Relationship between pattern electroretinogram and optic disc morphology in glaucoma
title_short Relationship between pattern electroretinogram and optic disc morphology in glaucoma
title_sort relationship between pattern electroretinogram and optic disc morphology in glaucoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837750/
https://www.ncbi.nlm.nih.gov/pubmed/31697709
http://dx.doi.org/10.1371/journal.pone.0220992
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