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Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data

Tumors are made of evolving and heterogeneous populations of cells which arise from successive appearance and expansion of subclonal populations, following acquisition of mutations conferring them a selective advantage. Those subclonal populations can be sensitive or resistant to different treatment...

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Detalles Bibliográficos
Autores principales:	Abécassis, Judith, Hamy, Anne-Sophie, Laurent, Cécile, Sadacca, Benjamin, Bonsang-Kitzis, Hélène, Reyal, Fabien, Vert, Jean-Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837753/ https://www.ncbi.nlm.nih.gov/pubmed/31697689 http://dx.doi.org/10.1371/journal.pone.0224143

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