The utility of adrenal and ovarian venous sampling in a progesterone-producing adrenal tumor and review of the literature

PURPOSE: A clinical case presenting secondary amenorrhea accompanied by an adrenal adenoma and hyperprogesteronemia is described in this study. METHODS: Selective catheterization and sampling of adrenal and ovarian veins were performed. RESULTS: The source of hyperprogesteronemia was located in the right adrenal gland. A progesterone-producing tumor in the right adrenal gland was diagnosed and removed. Twenty-six days after tumor resection, menstruation occurred. CONCLUSIONS: Progesterone-producing tumors should be considered with the presence of an adrenal mass and hyperprogesteronemia. Combined adrenal and ovarian venous sampling may help to identify the source of progesterone secretion.