Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant

A noncoding polymorphism (rs78378222) in TP53, carried by scores of millions of people, was previously associated with moderate risk of brain tumors and other neoplasms. We find a positive association between this variant and soft tissue sarcoma. In sharp contrast, it is protective against breast ca...

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Detalles Bibliográficos
Autores principales: Deng, Qipan, Hu, Hui, Yu, Xinfang, Liu, Shuanglin, Wang, Lei, Chen, Weiqun, Zhang, Chi, Zeng, Zhaoyang, Cao, Ya, Xu-Monette, Zijun Y., Li, Ling, Zhang, Mingzhi, Rosenfeld, Steven, Bao, Shideng, Hsi, Eric, Young, Ken H., Lu, Zhongxin, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838078/
https://www.ncbi.nlm.nih.gov/pubmed/31699989
http://dx.doi.org/10.1038/s41467-019-13002-x

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