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Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by...

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Autores principales: Jeong, Soyeon, Jo, Min Jee, Yun, Hye Kyeong, Kim, Dae Yeong, Kim, Bo Ram, Kim, Jung Lim, Park, Seong Hye, Na, Yoo Jin, Jeong, Yoon A, Kim, Bu Gyeom, Ashktorab, Hassan, Smoot, Duane T., Heo, Jun Young, Han, Jeongsu, Il Lee, Sun, Do Kim, Han, Kim, Dae Hyun, Oh, Sang Cheul, Lee, Dae-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838113/
https://www.ncbi.nlm.nih.gov/pubmed/31699976
http://dx.doi.org/10.1038/s41419-019-2001-7
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author Jeong, Soyeon
Jo, Min Jee
Yun, Hye Kyeong
Kim, Dae Yeong
Kim, Bo Ram
Kim, Jung Lim
Park, Seong Hye
Na, Yoo Jin
Jeong, Yoon A
Kim, Bu Gyeom
Ashktorab, Hassan
Smoot, Duane T.
Heo, Jun Young
Han, Jeongsu
Il Lee, Sun
Do Kim, Han
Kim, Dae Hyun
Oh, Sang Cheul
Lee, Dae-Hee
author_facet Jeong, Soyeon
Jo, Min Jee
Yun, Hye Kyeong
Kim, Dae Yeong
Kim, Bo Ram
Kim, Jung Lim
Park, Seong Hye
Na, Yoo Jin
Jeong, Yoon A
Kim, Bu Gyeom
Ashktorab, Hassan
Smoot, Duane T.
Heo, Jun Young
Han, Jeongsu
Il Lee, Sun
Do Kim, Han
Kim, Dae Hyun
Oh, Sang Cheul
Lee, Dae-Hee
author_sort Jeong, Soyeon
collection PubMed
description According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels while increasing ubiquitination of XIAP. The expression of Smac, a known inhibitor of XIAP, was found to be elevated during CBD treatment. Moreover, CBD treatment increased the interaction between XIAP and Smac by increasing Smac release from mitochondria to the cytosol. CBD has also been shown to affect mitochondrial dysfunction. Taken together, these results suggest that CBD may have potential as a new therapeutic target in gastric cancer.
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spelling pubmed-68381132019-11-13 Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer Jeong, Soyeon Jo, Min Jee Yun, Hye Kyeong Kim, Dae Yeong Kim, Bo Ram Kim, Jung Lim Park, Seong Hye Na, Yoo Jin Jeong, Yoon A Kim, Bu Gyeom Ashktorab, Hassan Smoot, Duane T. Heo, Jun Young Han, Jeongsu Il Lee, Sun Do Kim, Han Kim, Dae Hyun Oh, Sang Cheul Lee, Dae-Hee Cell Death Dis Article According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels while increasing ubiquitination of XIAP. The expression of Smac, a known inhibitor of XIAP, was found to be elevated during CBD treatment. Moreover, CBD treatment increased the interaction between XIAP and Smac by increasing Smac release from mitochondria to the cytosol. CBD has also been shown to affect mitochondrial dysfunction. Taken together, these results suggest that CBD may have potential as a new therapeutic target in gastric cancer. Nature Publishing Group UK 2019-11-07 /pmc/articles/PMC6838113/ /pubmed/31699976 http://dx.doi.org/10.1038/s41419-019-2001-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jeong, Soyeon
Jo, Min Jee
Yun, Hye Kyeong
Kim, Dae Yeong
Kim, Bo Ram
Kim, Jung Lim
Park, Seong Hye
Na, Yoo Jin
Jeong, Yoon A
Kim, Bu Gyeom
Ashktorab, Hassan
Smoot, Duane T.
Heo, Jun Young
Han, Jeongsu
Il Lee, Sun
Do Kim, Han
Kim, Dae Hyun
Oh, Sang Cheul
Lee, Dae-Hee
Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
title Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
title_full Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
title_fullStr Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
title_full_unstemmed Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
title_short Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
title_sort cannabidiol promotes apoptosis via regulation of xiap/smac in gastric cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838113/
https://www.ncbi.nlm.nih.gov/pubmed/31699976
http://dx.doi.org/10.1038/s41419-019-2001-7
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