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Functional connectivity underlying hedonic response to food in female adolescents with atypical AN: the role of somatosensory and salience networks

Atypical anorexia nervosa (AN) usually occurs during adolescence. Patients are often in the normal-weight range at diagnosis; however, they often present with signs of medical complications and severe restraint over eating, body dissatisfaction, and low self-esteem. We investigated functional circui...

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Autores principales: Olivo, Gaia, Zhukovsky, Christina, Salonen-Ros, Helena, Larsson, Elna-Marie, Brooks, Samantha, Schiöth, Helgi B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838122/
https://www.ncbi.nlm.nih.gov/pubmed/31699967
http://dx.doi.org/10.1038/s41398-019-0617-0
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author Olivo, Gaia
Zhukovsky, Christina
Salonen-Ros, Helena
Larsson, Elna-Marie
Brooks, Samantha
Schiöth, Helgi B.
author_facet Olivo, Gaia
Zhukovsky, Christina
Salonen-Ros, Helena
Larsson, Elna-Marie
Brooks, Samantha
Schiöth, Helgi B.
author_sort Olivo, Gaia
collection PubMed
description Atypical anorexia nervosa (AN) usually occurs during adolescence. Patients are often in the normal-weight range at diagnosis; however, they often present with signs of medical complications and severe restraint over eating, body dissatisfaction, and low self-esteem. We investigated functional circuitry underlying the hedonic response in 28 female adolescent patients diagnosed with atypical AN and 33 healthy controls. Participants were shown images of food with high (HC) or low (LC) caloric content in alternating blocks during functional MRI. The HC > LC contrast was calculated. Based on the previous literature on full-threshold AN, we hypothesized that patients would exhibit increased connectivity in areas involved in sensory processing and bottom-up responses, coupled to increased connectivity from areas related to top-down inhibitory control, compared with controls. Patients showed increased connectivity in pathways related to multimodal somatosensory processing and memory retrieval. The connectivity was on the other hand decreased in patients in salience and attentional networks, and in a wide cerebello-occipital network. Our study was the first investigation of food-related neural response in atypical AN. Our findings support higher somatosensory processing in patients in response to HC food images compared with controls, however HC food was less efficient than LC food in engaging patients’ bottom-up salient responses, and was not associated with connectivity increases in inhibitory control regions. These findings suggest that the psychopathological mechanisms underlying food restriction in atypical AN differ from full-threshold AN. Elucidating the mechanisms underlying the development and maintenance of eating behavior in atypical AN might help designing specific treatment strategies.
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spelling pubmed-68381222019-11-14 Functional connectivity underlying hedonic response to food in female adolescents with atypical AN: the role of somatosensory and salience networks Olivo, Gaia Zhukovsky, Christina Salonen-Ros, Helena Larsson, Elna-Marie Brooks, Samantha Schiöth, Helgi B. Transl Psychiatry Article Atypical anorexia nervosa (AN) usually occurs during adolescence. Patients are often in the normal-weight range at diagnosis; however, they often present with signs of medical complications and severe restraint over eating, body dissatisfaction, and low self-esteem. We investigated functional circuitry underlying the hedonic response in 28 female adolescent patients diagnosed with atypical AN and 33 healthy controls. Participants were shown images of food with high (HC) or low (LC) caloric content in alternating blocks during functional MRI. The HC > LC contrast was calculated. Based on the previous literature on full-threshold AN, we hypothesized that patients would exhibit increased connectivity in areas involved in sensory processing and bottom-up responses, coupled to increased connectivity from areas related to top-down inhibitory control, compared with controls. Patients showed increased connectivity in pathways related to multimodal somatosensory processing and memory retrieval. The connectivity was on the other hand decreased in patients in salience and attentional networks, and in a wide cerebello-occipital network. Our study was the first investigation of food-related neural response in atypical AN. Our findings support higher somatosensory processing in patients in response to HC food images compared with controls, however HC food was less efficient than LC food in engaging patients’ bottom-up salient responses, and was not associated with connectivity increases in inhibitory control regions. These findings suggest that the psychopathological mechanisms underlying food restriction in atypical AN differ from full-threshold AN. Elucidating the mechanisms underlying the development and maintenance of eating behavior in atypical AN might help designing specific treatment strategies. Nature Publishing Group UK 2019-11-07 /pmc/articles/PMC6838122/ /pubmed/31699967 http://dx.doi.org/10.1038/s41398-019-0617-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Olivo, Gaia
Zhukovsky, Christina
Salonen-Ros, Helena
Larsson, Elna-Marie
Brooks, Samantha
Schiöth, Helgi B.
Functional connectivity underlying hedonic response to food in female adolescents with atypical AN: the role of somatosensory and salience networks
title Functional connectivity underlying hedonic response to food in female adolescents with atypical AN: the role of somatosensory and salience networks
title_full Functional connectivity underlying hedonic response to food in female adolescents with atypical AN: the role of somatosensory and salience networks
title_fullStr Functional connectivity underlying hedonic response to food in female adolescents with atypical AN: the role of somatosensory and salience networks
title_full_unstemmed Functional connectivity underlying hedonic response to food in female adolescents with atypical AN: the role of somatosensory and salience networks
title_short Functional connectivity underlying hedonic response to food in female adolescents with atypical AN: the role of somatosensory and salience networks
title_sort functional connectivity underlying hedonic response to food in female adolescents with atypical an: the role of somatosensory and salience networks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838122/
https://www.ncbi.nlm.nih.gov/pubmed/31699967
http://dx.doi.org/10.1038/s41398-019-0617-0
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