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Quantitative Gait Analysis and Cerebrospinal Fluid Tap Test for Idiopathic Normal-pressure Hydrocephalus

We investigated gait performance utilizing a quantitative gait analysis for 2 groups: (1) idiopathic normal-pressure hydrocephalus (INPH) patients who had a positive response to the cerebrospinal fluid tap test (CSFTT) and (2) healthy controls. The aims of the study were (1) to analyze the character...

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Autores principales: Lim, Yong-Hyun, Ko, Pan-Woo, Park, Ki-Su, Hwang, Sung Kyoo, Kim, Sung-Hee, Han, Jaehwan, Yoon, Uicheul, Lee, Ho-Won, Kang, Kyunghun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838166/
https://www.ncbi.nlm.nih.gov/pubmed/31700018
http://dx.doi.org/10.1038/s41598-019-52448-3
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author Lim, Yong-Hyun
Ko, Pan-Woo
Park, Ki-Su
Hwang, Sung Kyoo
Kim, Sung-Hee
Han, Jaehwan
Yoon, Uicheul
Lee, Ho-Won
Kang, Kyunghun
author_facet Lim, Yong-Hyun
Ko, Pan-Woo
Park, Ki-Su
Hwang, Sung Kyoo
Kim, Sung-Hee
Han, Jaehwan
Yoon, Uicheul
Lee, Ho-Won
Kang, Kyunghun
author_sort Lim, Yong-Hyun
collection PubMed
description We investigated gait performance utilizing a quantitative gait analysis for 2 groups: (1) idiopathic normal-pressure hydrocephalus (INPH) patients who had a positive response to the cerebrospinal fluid tap test (CSFTT) and (2) healthy controls. The aims of the study were (1) to analyze the characteristics of gait features, (2) to characterize changes in gait parameters before and after the CSFTT, and (3) to determine whether there was any relationship between stride time and stride length variability and Frontal Assessment Battery (FAB) scores in INPH patients. Twenty-three INPH patients and 17 healthy controls were included in this study. Compared with healthy controls, the gait of INPH patients was characterized by lower velocity, shorter stride length, and more broad-based gait. Patients with INPH had a longer stance phase with increased double-limb support. Variability in stride time and stride length was increased in INPH patients. Stride time and stride length variability were correlated with FAB score. After the CSFTT, gait velocity, stride length, and step width significantly improved. There were significant decreases in stride time and stride length variability. These results suggest that the CSFTT for INPH patients might improve the so-called balance-related gait parameter (ie, step width) as well. Stride time and stride length variability also responded to the CSFTT. Association between FAB scores and both stride time and stride length variability suggests involvement of similar circuits producing gait variability and frontal lobe functions in INPH patients.
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spelling pubmed-68381662019-11-14 Quantitative Gait Analysis and Cerebrospinal Fluid Tap Test for Idiopathic Normal-pressure Hydrocephalus Lim, Yong-Hyun Ko, Pan-Woo Park, Ki-Su Hwang, Sung Kyoo Kim, Sung-Hee Han, Jaehwan Yoon, Uicheul Lee, Ho-Won Kang, Kyunghun Sci Rep Article We investigated gait performance utilizing a quantitative gait analysis for 2 groups: (1) idiopathic normal-pressure hydrocephalus (INPH) patients who had a positive response to the cerebrospinal fluid tap test (CSFTT) and (2) healthy controls. The aims of the study were (1) to analyze the characteristics of gait features, (2) to characterize changes in gait parameters before and after the CSFTT, and (3) to determine whether there was any relationship between stride time and stride length variability and Frontal Assessment Battery (FAB) scores in INPH patients. Twenty-three INPH patients and 17 healthy controls were included in this study. Compared with healthy controls, the gait of INPH patients was characterized by lower velocity, shorter stride length, and more broad-based gait. Patients with INPH had a longer stance phase with increased double-limb support. Variability in stride time and stride length was increased in INPH patients. Stride time and stride length variability were correlated with FAB score. After the CSFTT, gait velocity, stride length, and step width significantly improved. There were significant decreases in stride time and stride length variability. These results suggest that the CSFTT for INPH patients might improve the so-called balance-related gait parameter (ie, step width) as well. Stride time and stride length variability also responded to the CSFTT. Association between FAB scores and both stride time and stride length variability suggests involvement of similar circuits producing gait variability and frontal lobe functions in INPH patients. Nature Publishing Group UK 2019-11-07 /pmc/articles/PMC6838166/ /pubmed/31700018 http://dx.doi.org/10.1038/s41598-019-52448-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lim, Yong-Hyun
Ko, Pan-Woo
Park, Ki-Su
Hwang, Sung Kyoo
Kim, Sung-Hee
Han, Jaehwan
Yoon, Uicheul
Lee, Ho-Won
Kang, Kyunghun
Quantitative Gait Analysis and Cerebrospinal Fluid Tap Test for Idiopathic Normal-pressure Hydrocephalus
title Quantitative Gait Analysis and Cerebrospinal Fluid Tap Test for Idiopathic Normal-pressure Hydrocephalus
title_full Quantitative Gait Analysis and Cerebrospinal Fluid Tap Test for Idiopathic Normal-pressure Hydrocephalus
title_fullStr Quantitative Gait Analysis and Cerebrospinal Fluid Tap Test for Idiopathic Normal-pressure Hydrocephalus
title_full_unstemmed Quantitative Gait Analysis and Cerebrospinal Fluid Tap Test for Idiopathic Normal-pressure Hydrocephalus
title_short Quantitative Gait Analysis and Cerebrospinal Fluid Tap Test for Idiopathic Normal-pressure Hydrocephalus
title_sort quantitative gait analysis and cerebrospinal fluid tap test for idiopathic normal-pressure hydrocephalus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838166/
https://www.ncbi.nlm.nih.gov/pubmed/31700018
http://dx.doi.org/10.1038/s41598-019-52448-3
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