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Gut Microbiota-Mediated Drug-Drug Interaction between Amoxicillin and Aspirin
The effects of antibiotics on the intestinal flora can create potential drug-drug interactions. The combination of amoxicillin and aspirin is high and there is a high probability of interaction. We used 16S rRNA, incubation experiments and liquid chromatography-tandem mass spectrometry to analyze ra...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838174/ https://www.ncbi.nlm.nih.gov/pubmed/31700098 http://dx.doi.org/10.1038/s41598-019-52632-5 |
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author | Zhang, Juanhong Sun, Yuemei Wang, Rong Zhang, Junmin |
author_facet | Zhang, Juanhong Sun, Yuemei Wang, Rong Zhang, Junmin |
author_sort | Zhang, Juanhong |
collection | PubMed |
description | The effects of antibiotics on the intestinal flora can create potential drug-drug interactions. The combination of amoxicillin and aspirin is high and there is a high probability of interaction. We used 16S rRNA, incubation experiments and liquid chromatography-tandem mass spectrometry to analyze rat biological samples to characterize the effect of amoxicillin on the pharmacokinetics of aspirin metabolites. We first discovered that amoxicillin reduced the species and number of intestinal flora in rats, such as reducing the abundance of Helicobacter pylori and Prevotella_copri. After 12, 24, and 36 hours of incubation, the remaining amount of aspirin in the aspirin and amoxicillin treatment groups decreased, and salicylic acid production increased, suggesting that aspirin is metabolized by the intestinal flora, and the main metabolite is salicylic acid. As the incubation time prolonged, the reduction of aspirin and the production of salicylic acid in the amoxicillin treatment group were slower. It is indicated that the metabolic activity of aspirin through the intestinal flora is slowed down after administration of amoxicillin. The pharmacokinetic experiments showed that after administration of amoxicillin, the area under the salicylic acid curve increased by 91.38%, the peak concentration increased by 60.43%, and the clearance rate decreased by 43.55%.The results demonstrated that amoxicillin affected the pharmacokinetics of aspirin active metabolite salicylic acid by slowing down the metabolic activity of intestinal flora on aspirin. The interaction between amoxicillin and aspirin mediated by the intestinal flora may affect the efficacy of aspirin and cause more significant adverse effects. |
format | Online Article Text |
id | pubmed-6838174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68381742019-11-14 Gut Microbiota-Mediated Drug-Drug Interaction between Amoxicillin and Aspirin Zhang, Juanhong Sun, Yuemei Wang, Rong Zhang, Junmin Sci Rep Article The effects of antibiotics on the intestinal flora can create potential drug-drug interactions. The combination of amoxicillin and aspirin is high and there is a high probability of interaction. We used 16S rRNA, incubation experiments and liquid chromatography-tandem mass spectrometry to analyze rat biological samples to characterize the effect of amoxicillin on the pharmacokinetics of aspirin metabolites. We first discovered that amoxicillin reduced the species and number of intestinal flora in rats, such as reducing the abundance of Helicobacter pylori and Prevotella_copri. After 12, 24, and 36 hours of incubation, the remaining amount of aspirin in the aspirin and amoxicillin treatment groups decreased, and salicylic acid production increased, suggesting that aspirin is metabolized by the intestinal flora, and the main metabolite is salicylic acid. As the incubation time prolonged, the reduction of aspirin and the production of salicylic acid in the amoxicillin treatment group were slower. It is indicated that the metabolic activity of aspirin through the intestinal flora is slowed down after administration of amoxicillin. The pharmacokinetic experiments showed that after administration of amoxicillin, the area under the salicylic acid curve increased by 91.38%, the peak concentration increased by 60.43%, and the clearance rate decreased by 43.55%.The results demonstrated that amoxicillin affected the pharmacokinetics of aspirin active metabolite salicylic acid by slowing down the metabolic activity of intestinal flora on aspirin. The interaction between amoxicillin and aspirin mediated by the intestinal flora may affect the efficacy of aspirin and cause more significant adverse effects. Nature Publishing Group UK 2019-11-07 /pmc/articles/PMC6838174/ /pubmed/31700098 http://dx.doi.org/10.1038/s41598-019-52632-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhang, Juanhong Sun, Yuemei Wang, Rong Zhang, Junmin Gut Microbiota-Mediated Drug-Drug Interaction between Amoxicillin and Aspirin |
title | Gut Microbiota-Mediated Drug-Drug Interaction between Amoxicillin and Aspirin |
title_full | Gut Microbiota-Mediated Drug-Drug Interaction between Amoxicillin and Aspirin |
title_fullStr | Gut Microbiota-Mediated Drug-Drug Interaction between Amoxicillin and Aspirin |
title_full_unstemmed | Gut Microbiota-Mediated Drug-Drug Interaction between Amoxicillin and Aspirin |
title_short | Gut Microbiota-Mediated Drug-Drug Interaction between Amoxicillin and Aspirin |
title_sort | gut microbiota-mediated drug-drug interaction between amoxicillin and aspirin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838174/ https://www.ncbi.nlm.nih.gov/pubmed/31700098 http://dx.doi.org/10.1038/s41598-019-52632-5 |
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