Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins

Protein interactions of Tau are of interest in efforts to decipher pathogenesis in Alzheimer’s disease, a subset of frontotemporal dementias, and other tauopathies. We CRISPR-Cas9 edited two human cell lines to generate broadly adaptable models for neurodegeneration research. We applied the system t...

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Detalles Bibliográficos
Autores principales: Wang, Xinzhu, Williams, Declan, Müller, Iris, Lemieux, Mackenzie, Dukart, Ramona, Maia, Isabella B. L., Wang, Hansen, Woerman, Amanda L., Schmitt-Ulms, Gerold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838314/
https://www.ncbi.nlm.nih.gov/pubmed/31700063
http://dx.doi.org/10.1038/s41598-019-52543-5

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