Cargando…

Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice

Recent evidences indicate that signal transducer and activator of transcription 3 (STAT3) is one of the crucial signaling pathways in the progression of diabetic nephropathy (DN). Here, we investigated the hypothesis that pharmacological blockade of STAT3 limits the progression of DN. Treatment with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Chao, Huang, Lan, Luo, Wu, Yu, Weihui, Hu, Xueting, Guan, Xinfu, Cai, Yan, Zou, Chunpeng, Yin, Haimin, Xu, Zheng, Liang, Guang, Wang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838321/ https://www.ncbi.nlm.nih.gov/pubmed/31699972 http://dx.doi.org/10.1038/s41419-019-2085-0

Ejemplares similares

Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2)
por: Xu, Zheng, et al.
Publicado: (2017)

Protective Effects of Luteolin on Diabetic Nephropathy in STZ-Induced Diabetic Rats
por: Wang, Guo Guang, et al.
Publicado: (2011)

Motile Cilia on Kidney Proximal Tubular Epithelial Cells Are Associated With Tubular Injury and Interstitial Fibrosis
por: Eymael, Jennifer, et al.
Publicado: (2022)

Fenugreek Prevents the Development of STZ-Induced Diabetic Nephropathy in a Rat Model of Diabetes
por: Jin, Yingli, et al.
Publicado: (2014)

Author Correction: Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2)
por: Xu, Zheng, et al.
Publicado: (2021)

Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury
por: Xie, Qionghong, et al.
Publicado: (2022)

Inhibition of MAPK-mediated ACE expression by compound C66 prevents STZ-induced diabetic nephropathy
por: Pan, Yong, et al.
Publicado: (2014)

Autophagy activation contributes to lipid accumulation in tubular epithelial cells during kidney fibrosis
por: Yan, Qi, et al.
Publicado: (2018)

Lysine Acetylation in the Proteome of Renal Tubular Epithelial Cells in Diabetic Nephropathy
por: Wan, Jiayi, et al.
Publicado: (2021)

Novel aspect of neprilysin in kidney fibrosis via ACSL4‐mediated ferroptosis of tubular epithelial cells
por: Lai, Weijing, et al.
Publicado: (2023)

Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy
por: Maydan, Olena, et al.
Publicado: (2018)

Ameliorative effect of Cephalandra indica homeopathic preparation in STZ induced diabetic nephropathy rats
por: Kishore, Lalit, et al.
Publicado: (2019)

Effect of Selenium Nanoparticles and/or Bee Venom against STZ-Induced Diabetic Cardiomyopathy and Nephropathy
por: Lotfy, Mona M., et al.
Publicado: (2023)

Cellular senescence of renal tubular epithelial cells in renal fibrosis
por: Zhang, Jun-Qing, et al.
Publicado: (2023)

Nephropathy Is Aggravated by Fatty Acids in Diabetic Kidney Disease through Tubular Epithelial Cell Necroptosis and Is Alleviated by an RIPK-1 Inhibitor
por: Yu, Qi, et al.
Publicado: (2023)

Effects of Exosomes Derived from Kidney Tubular Cells on Diabetic Nephropathy in Rats
por: Fakhredini, Fereshtesadat, et al.
Publicado: (2022)

Activation of the NLRC4 inflammasome in renal tubular epithelial cell injury in diabetic nephropathy
por: Wang, Yulin, et al.
Publicado: (2021)

The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy
por: Zhao, Weichen, et al.
Publicado: (2022)

CCN2 Binds to Tubular Epithelial Cells in the Kidney
por: Rayego-Mateos, Sandra, et al.
Publicado: (2022)

Hypoxia Induces Mesenchymal Gene Expression in Renal Tubular Epithelial Cells: An in vitro Model of Kidney Transplant Fibrosis
por: Zell, Stephanie, et al.
Publicado: (2013)

Vitamin D and chronic kidney disease: Insights on lipid metabolism of tubular epithelial cell and macrophages in tubulointerstitial fibrosis
por: Gonçalves, Luís Eduardo D., et al.
Publicado: (2023)

Inactivation of TSC1 promotes epithelial-mesenchymal transition of renal tubular epithelial cells in mouse diabetic nephropathy
por: Lu, Qian, et al.
Publicado: (2019)

Crucial role of serum response factor in renal tubular epithelial cell epithelial-mesenchymal transition in hyperuricemic nephropathy
por: Zhao, Long, et al.
Publicado: (2019)

Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation
por: Zheng, Meiling, et al.
Publicado: (2019)

Decoy receptor 2 mediates the apoptosis-resistant phenotype of senescent renal tubular cells and accelerates renal fibrosis in diabetic nephropathy
por: Chen, Jia, et al.
Publicado: (2022)

Inhibiting the urokinase‐type plasminogen activator receptor system recovers STZ‐induced diabetic nephropathy
por: Dal Monte, Massimo, et al.
Publicado: (2018)

Role of SUMOylation of STAT1 in tubular epithelial-mesenchymal transition induced by high glucose
por: Gu, Cunyang, et al.
Publicado: (2023)

Tilapia Skin Peptides Ameliorate Diabetic Nephropathy in STZ-Induced Diabetic Rats and HG-Induced GMCs by Improving Mitochondrial Dysfunction
por: Jin, Lin, et al.
Publicado: (2020)

Buyang Huanwu Decoction protects against STZ-induced diabetic nephropathy by inhibiting TGF-β/Smad3 signaling-mediated renal fibrosis and inflammation
por: Wu, Weifeng, et al.
Publicado: (2021)

Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting tubular epithelial-mesenchymal transition in vivo and in vitro
por: SHAN, GUANG, et al.
Publicado: (2016)

Epithelial–Mesenchymal Transition in Kidney Tubular Epithelial Cells Induced by Globotriaosylsphingosine and Globotriaosylceramide
por: Jeon, Yeo Jin, et al.
Publicado: (2015)

Metformin Reduces the Senescence of Renal Tubular Epithelial Cells in Diabetic Nephropathy via the MBNL1/miR-130a-3p/STAT3 Pathway
por: Jiang, Xue, et al.
Publicado: (2020)

HNRNPA1-mediated exosomal sorting of miR-483-5p out of renal tubular epithelial cells promotes the progression of diabetic nephropathy-induced renal interstitial fibrosis
por: Liu, DongWei, et al.
Publicado: (2021)

Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy
por: Wang, Shujun, et al.
Publicado: (2022)

Exendin-4 ameliorates high glucose-induced fibrosis by inhibiting the secretion of miR-192 from injured renal tubular epithelial cells
por: Jia, Yijie, et al.
Publicado: (2018)

Epithelial-mesenchymal transition and apoptosis of renal tubular epithelial cells are associated with disease progression in patients with IgA nephropathy
por: YAO, JUNXIA, et al.
Publicado: (2014)

Significance of Multinucleated Polyploidization of Tubular Epithelial Cells in Kidney Allografts
por: Kounoue, Noriyuki, et al.
Publicado: (2023)

Kidney-targeted baicalin-lysozyme conjugate ameliorates renal fibrosis in rats with diabetic nephropathy induced by streptozotocin
por: Zheng, Xiao-peng, et al.
Publicado: (2020)

EGFR inhibition attenuates diabetic nephropathy through decreasing ROS and endoplasmic reticulum stress
por: Xu, Zheng, et al.
Publicado: (2017)

Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways
por: Lei, Lei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_31a9nfrc9rjfu0kr246rte75sb