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Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9

BACKGROUND: Cartilaginous endplate (CEP) degeneration is considered as one of the major causes of intervertebral disc degeneration (IVDD) which causes low back pain. Recent studies have proved that epigenetic alteration is involved in a variety of diseases. This work explored the role of histone met...

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Detalles Bibliográficos
Autores principales:	Jiang, Chao, Guo, Qiang, Jin, Yu, Xu, Jia-Jing, Sun, Ze-Ming, Zhu, Ding-Chao, Lin, Jia-Hao, Tian, Nai-Feng, Sun, Liao-Jun, Zhang, Xiao-Lei, Wu, Yao-Sen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838408/ https://www.ncbi.nlm.nih.gov/pubmed/31631036 http://dx.doi.org/10.1016/j.ebiom.2019.10.006

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