DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients’ survival, immune cell infiltrates, mutational load, and interferon γ signature

BACKGROUND: The immune checkpoint, indoleamine 2,3-dioxygenase 1, is under investigation as target of novel immunotherapies for cancers, including head and neck squamous cell carcinomas (HNSCC). The aim of our study was to analyze DNA methylation of the encoding gene (IDO1) in HNSCC. METHODS: Methyl...

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Detalles Bibliográficos
Autores principales: Sailer, Verena, Sailer, Ulrike, Bawden, Emma Grace, Zarbl, Romina, Wiek, Constanze, Vogt, Timo J., Dietrich, Joern, Loick, Sophia, Grünwald, Ingela, Toma, Marieta, Golletz, Carsten, Gerstner, Andreas, Kristiansen, Glen, Bootz, Friedrich, Scheckenbach, Kathrin, Landsberg, Jennifer, Dietrich, Dimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838413/
https://www.ncbi.nlm.nih.gov/pubmed/31628024
http://dx.doi.org/10.1016/j.ebiom.2019.09.038

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