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FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease

BACKGROUND: Tubulointerstitial fibrosis (TIF) plays an important role in the progression of diabetic kidney disease (DKD). Forkhead box O1 (FoxO1) is involved in the regulation of metabolism and cell apoptosis, but its function in renal TIF induced by DKD is less well understood. METHODS: Human kidn...

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Detalles Bibliográficos
Autores principales:	Huang, Fengjuan, Wang, Qingzhu, Guo, Feng, Zhao, Yanyan, Ji, Linlin, An, Tingting, Song, Yi, Liu, Yang, He, Yanyan, Qin, Guijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838438/ https://www.ncbi.nlm.nih.gov/pubmed/31629675 http://dx.doi.org/10.1016/j.ebiom.2019.09.002

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