High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation

BACKGROUND: Urea, the end product of protein metabolism, has been considered to have negligible toxicity for a long time. Our previous study showed a depression phenotype in urea transporter (UT) B knockout mice, which suggests that abnormal urea metabolism may cause depression. The purpose of this...

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Detalles Bibliográficos
Autores principales: Wang, Hongkai, Huang, Boyue, Wang, Weiling, Li, Jinfang, Chen, Yi, Flynn, Trevor, Zhao, Meng, Zhou, Zhiming, Lin, Xiaojing, Zhang, Yinan, Xu, Mengmeng, Li, Keqiong, Tian, Kuan, Yuan, Dezhi, Zhou, Peng, Hu, Ling, Zhong, Dandan, Zhu, Shuai, Li, Jing, Chen, Dilong, Wang, Kejian, Liang, Jianhui, He, Qihua, Sun, Jianbin, Shi, Jie, Yan, Li, Sands, Jeff M, Xie, Zhengwei, Lian, Xuemei, Xu, Duan, Ran, Jianhua, Yang, Baoxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838447/
https://www.ncbi.nlm.nih.gov/pubmed/31628020
http://dx.doi.org/10.1016/j.ebiom.2019.09.049

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